Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol

Hsing Pang Hsieh; Ying Ta Wu; Shui Tein Chen; Kung Tsung Wang

doi:10.1039/a707934f

Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol

Hsing Pang Hsieh
, Ying Ta Wu
, Shui Tein Chen
, Kung Tsung Wang

Center of Applied Nanomedicine

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Dihydropyran-2-carboxylic acid, a novel compound used to link an amino alcohol and an amine resin, is utilised for the solid-phase synthesis of peptide alcohols via the Fmoc strategy; this bifunctional linker was effectively applied to the synthesis of Octreotide.

Original language	English
Pages (from-to)	649-650
Number of pages	2
Journal	Chemical Communications
Issue number	6
DOIs	https://doi.org/10.1039/a707934f
Publication status	Published - 1998 Mar 21

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/a707934f

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title = "Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol",

abstract = "Dihydropyran-2-carboxylic acid, a novel compound used to link an amino alcohol and an amine resin, is utilised for the solid-phase synthesis of peptide alcohols via the Fmoc strategy; this bifunctional linker was effectively applied to the synthesis of Octreotide.",

author = "Hsieh, \{Hsing Pang\} and Wu, \{Ying Ta\} and Chen, \{Shui Tein\} and Wang, \{Kung Tsung\}",

year = "1998",

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journal = "Chemical Communications",

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AU - Hsieh, Hsing Pang

AU - Wu, Ying Ta

AU - Chen, Shui Tein

AU - Wang, Kung Tsung

PY - 1998/3/21

Y1 - 1998/3/21

N2 - Dihydropyran-2-carboxylic acid, a novel compound used to link an amino alcohol and an amine resin, is utilised for the solid-phase synthesis of peptide alcohols via the Fmoc strategy; this bifunctional linker was effectively applied to the synthesis of Octreotide.

AB - Dihydropyran-2-carboxylic acid, a novel compound used to link an amino alcohol and an amine resin, is utilised for the solid-phase synthesis of peptide alcohols via the Fmoc strategy; this bifunctional linker was effectively applied to the synthesis of Octreotide.

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UR - https://www.scopus.com/pages/publications/0032554563#tab=citedBy

U2 - 10.1039/a707934f

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SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol

Abstract

All Science Journal Classification (ASJC) codes

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