Direct radiofrequency application improves pain and gait in collagenase-induced acute achilles tendon injury

Yun Pu Tsai, Chi Wen Chang, Jung Shun Lee, Jen I. Liang, Tsung Hsun Hsieh, Ming Long Yeh, Chun I. Sze

Research output: Contribution to journalArticle

4 Citations (Scopus)


Radiofrequency (RF) is often used as a supplementary and alternative method to alleviate pain for chronic tendinopathy. Whether or how it would work for acute tendon injury is not addressed in the literatures. Through detailed pain and gait monitoring, we hypothesized that collagenase-induce acute tendinopathy model may be able to answer these questions. Gait parameters, including time, distance, and range of motion, were recorded and analyzed using a walking track equipped with a video-based system. Expression of substance P (SP), calcitonin gene related peptide (CGRP), and galanin were used as pain markers. Beta-III tubulin and Masson trichrome staining were used as to evaluate nerve sprouting, matrix tension, and degeneration in the tendon. Of fourteen analyzed parameters, RF significantly improved stance phase, step length, preswing, and intermediary toe-spread of gait. Improved gait related to the expression of substance P, CGRP, and reduced nerve fiber sprouting and matrix tension, but not galanin. The study indicates that direct RF application may be a valuable approach to improve gait and pain in acute tendon injury. Altered gait parameters may be used as references to evaluate therapeutic outcomes of RF or other treatment plan for tendinopathy.

Original languageEnglish
Article number402692
JournalEvidence-based Complementary and Alternative Medicine
Publication statusPublished - 2013 Dec 1

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

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