DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

Woei-Jer Chuang (Inventor)

Research output: Patent

Abstract

Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin .alpha.v.beta.3 receptor-antagonist activity and substantially reduced integrin .alpha.llb.beta.3 and/or .alpha.5.beta.1 receptor-blocking activity as compared to a wild-type disintegrin.
Original languageEnglish
Patent number7943728
Publication statusPublished - 2008 Aug 7

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Disintegrins
Integrins
Pharmaceutical Preparations
Peptides

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Chuang, Woei-Jer (Inventor). / DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF. Patent No.: 7943728.
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Chuang, W-J 2008, DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF, Patent No. 7943728.

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF. / Chuang, Woei-Jer (Inventor).

Patent No.: 7943728.

Research output: Patent

TY - PAT

T1 - DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

AU - Chuang, Woei-Jer

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Y1 - 2008/8/7

N2 - Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin .alpha.v.beta.3 receptor-antagonist activity and substantially reduced integrin .alpha.llb.beta.3 and/or .alpha.5.beta.1 receptor-blocking activity as compared to a wild-type disintegrin.

AB - Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin .alpha.v.beta.3 receptor-antagonist activity and substantially reduced integrin .alpha.llb.beta.3 and/or .alpha.5.beta.1 receptor-blocking activity as compared to a wild-type disintegrin.

M3 - Patent

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Chuang W-J, inventor. DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF. 7943728. 2008 Aug 7.