Dispersion control in microfluidic chips by localized zeta potential variation using the field effect

Gwo Bin Lee, Lung-Ming Fu, Che Hsin Lin, Chia Yen Lee, Ruey-Jen Yang

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

A new technique to minimize the effects of turn-induced dispersion within U-shaped separation channels by using the field effect within a capacitor to vary the zeta potential along the channel walls in the vicinity of the microchannel is described. The effects of the separation channel geometry, the fluid velocity profile, and the use of the field effect to control the zeta potential on the band distribution in the detection area are extensively discussed. The results for a U-shaped separation channel indicate that varying the zeta potential by controlling the field effect significantly reduces the band dispersion induced by the 90° turns within the channel. Finally, it is shown that the application of the proposed localized zeta potential variation method also results in a correction of the band tilting phenomenon and a reduction in the racetrack effect.

Original languageEnglish
Pages (from-to)1879-1887
Number of pages9
JournalElectrophoresis
Volume25
Issue number12
DOIs
Publication statusPublished - 2004 Jun 1

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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