Disruption of model cell membranes by carbon nanotubes

Charlie Corredor, Wen-Che Hou, Steven A. Klein, Babak Y. Moghadam, Michael Goryll, Kyle Doudrick, Paul Westerhoff, Jonathan D. Posner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Carbon nanotubes (CNTs) have one of the highest production volumes among carbonaceous engineered nanoparticles (ENPs) worldwide and are have potential uses in applications including biomedicine, nanocomposites, and energy conversion. However, CNTs possible widespread usage and associated likelihood for biological exposures have driven concerns regarding their nanotoxicity and ecological impact. In this work, we probe the responses of planar suspended lipid bilayer membranes, used as model cell membranes, to functionalized multi-walled carbon nanotubes (MWCNT), CdSe/ZnS quantum dots, and a control organic compound, melittin, using an electrophysiological measurement platform. The electrophysiological measurements show that MWCNTs in a concentration range of 1.6-12 ppm disrupt lipid membranes by inducing significant transmembrane current fluxes, which suggest that MWCNTs insert and traverse the lipid bilayer membrane, forming transmembrane carbon nanotubes channels that allow the transport of ions. This paper demonstrates a direct measurement of ion migration across lipid bilayers induced by CNTs. Electrophysiological measurements can provide unique insights into the lipid bilayer-ENPs interactions and have the potential to serve as a preliminary screening tool for nanotoxicity.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalCarbon
Volume60
DOIs
Publication statusPublished - 2013 Aug 1

Fingerprint

Carbon Nanotubes
Cell membranes
Lipid bilayers
Carbon nanotubes
Membrane Lipids
Ions
Melitten
Nanoparticles
Membranes
Die casting inserts
Energy conversion
Organic compounds
Semiconductor quantum dots
Nanocomposites
Screening
Fluxes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Corredor, C., Hou, W-C., Klein, S. A., Moghadam, B. Y., Goryll, M., Doudrick, K., ... Posner, J. D. (2013). Disruption of model cell membranes by carbon nanotubes. Carbon, 60, 67-75. https://doi.org/10.1016/j.carbon.2013.03.057
Corredor, Charlie ; Hou, Wen-Che ; Klein, Steven A. ; Moghadam, Babak Y. ; Goryll, Michael ; Doudrick, Kyle ; Westerhoff, Paul ; Posner, Jonathan D. / Disruption of model cell membranes by carbon nanotubes. In: Carbon. 2013 ; Vol. 60. pp. 67-75.
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Corredor, C, Hou, W-C, Klein, SA, Moghadam, BY, Goryll, M, Doudrick, K, Westerhoff, P & Posner, JD 2013, 'Disruption of model cell membranes by carbon nanotubes', Carbon, vol. 60, pp. 67-75. https://doi.org/10.1016/j.carbon.2013.03.057

Disruption of model cell membranes by carbon nanotubes. / Corredor, Charlie; Hou, Wen-Che; Klein, Steven A.; Moghadam, Babak Y.; Goryll, Michael; Doudrick, Kyle; Westerhoff, Paul; Posner, Jonathan D.

In: Carbon, Vol. 60, 01.08.2013, p. 67-75.

Research output: Contribution to journalArticle

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Corredor C, Hou W-C, Klein SA, Moghadam BY, Goryll M, Doudrick K et al. Disruption of model cell membranes by carbon nanotubes. Carbon. 2013 Aug 1;60:67-75. https://doi.org/10.1016/j.carbon.2013.03.057