Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome

Chia-Yih Wang, Wei Yi Chen, Pao Yen Lai, Bon chu Chung

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in the nucleus and the centrosome. SF-1 moves dynamically in the nucleus, and SF-1 location and activity are dynamically regulated by post-translational modifications. In the centrosome, SF-1 maintains genomic integrity by controlling centrosome homeostasis. SF-1 prevents centrosome amplification by restricting aberrant activation of centrosomal DNA-PK. Upon SF-1 removal, DNA-PK is activated and centrosomes are amplified. This leads to genomic instability and cell growth defects. These data indicate that SF-1 at both the nucleus and the centrosome contributes to cell growth control, but the mechanisms of SF-1 action in different locations are different.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume371
Issue number1-2
DOIs
Publication statusPublished - 2013 May 22

Fingerprint

Steroidogenic Factor 1
Centrosome
Cell growth
DNA
Transcription
Cytoplasmic and Nuclear Receptors
Amplification
Genes
Chemical activation
Cells
Defects
Growth
Genomic Instability
Gonads
Post Translational Protein Processing
Energy Metabolism
Reproduction
Homeostasis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Wang, Chia-Yih ; Chen, Wei Yi ; Lai, Pao Yen ; Chung, Bon chu. / Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome. In: Molecular and Cellular Endocrinology. 2013 ; Vol. 371, No. 1-2. pp. 148-153.
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Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome. / Wang, Chia-Yih; Chen, Wei Yi; Lai, Pao Yen; Chung, Bon chu.

In: Molecular and Cellular Endocrinology, Vol. 371, No. 1-2, 22.05.2013, p. 148-153.

Research output: Contribution to journalReview article

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AB - Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in the nucleus and the centrosome. SF-1 moves dynamically in the nucleus, and SF-1 location and activity are dynamically regulated by post-translational modifications. In the centrosome, SF-1 maintains genomic integrity by controlling centrosome homeostasis. SF-1 prevents centrosome amplification by restricting aberrant activation of centrosomal DNA-PK. Upon SF-1 removal, DNA-PK is activated and centrosomes are amplified. This leads to genomic instability and cell growth defects. These data indicate that SF-1 at both the nucleus and the centrosome contributes to cell growth control, but the mechanisms of SF-1 action in different locations are different.

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