Distinct protective effects of a novel Akkermansia sp. BCRC 18949 against DSS-Induced colitis in mice

Chien Hsun Huang, Chih Ting Huang, Hsu Yun Tsai, Yi Chu Liao, Chiao Mei Lin, Pei Chen Chen, Jong Shian Liou, Chin Lin Hsu, Shih Hau Chiu, Chien Chi Chen, Sung Yuan Hsieh, Hsin Bai Zou, Cheng Chih Hsu, Pai Sheng Chen, Cheng Yuan Kao, Jhen Wei Ruan

Research output: Contribution to journalArticlepeer-review


The emergence of next-generation probiotics (NGPs) has illuminated new possibilities for improving various diseases through food-grade supplements. In this study, a new gut bacterial species, designated as Akkermansia sp. BCRC 18949, was isolated from the feces of a healthy Taiwanese adult. The phylogenetic tree and whole genome sequencing analyses confirmed that this human commensal is a novel species belonging to the genus Akkermansia. Our results reveals that BCRC 18949 exhibits distinct mucin utilization abilities compared to ATCC BAA-835. Importantly, BCRC 18949 shows enhanced protection against DSS-induced colitis, while both species contribute differentially to restoring barrier integrity in DSS-treated mice. Furthermore, BCRC 18949 significantly restores the expression of colonic rhythmic genes, suggesting its potential role in maintaining circadian rhythm in the colon during colitis. Our findings provide valuable insights into the functional diversity of Akkermansia species and their potential therapeutic applications for colitis.

Original languageEnglish
Article number106110
JournalJournal of Functional Foods
Publication statusPublished - 2024 Apr

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Distinct protective effects of a novel Akkermansia sp. BCRC 18949 against DSS-Induced colitis in mice'. Together they form a unique fingerprint.

Cite this