Distinct Somatic Discrimination Reflected by Laser-Evoked Potentials Using Scalp EEG Leads

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Discrimination is an important function in pain processing of the somatic cortex. The involvement of the somatic cortex has been studied using equivalent dipole analysis and neuroimaging, but the results are inconsistent. Scalp electroencephalography (EEG) can reflect functional changes of particular brain regions underneath a lead. However, the responses of EEG leads close to the somatic cortex in response to pain have not been systematically evaluated. The present study applied CO2 laser stimulation to the dorsum of the left hand. Laser-evoked potentials (LEPs) of C4, T3, and T4 leads and pain ratings in response to four stimulus intensities were analyzed. LEPs started earlier at the C4 and T4 leads. The onset latency and peak latency of LEPs for C4 and T4 leads were the same. Only 10 of 22 subjects (45 %) presented equivalent current dipoles within the primary somatosensory or motor cortices. LEP amplitudes of these leads increased as stimulation intensity increased. The stimulus–response pattern of the C4 lead was highly correlated with pain rating. In contrast, an S-shaped stimulus–response curve was obtained for the T3 and T4 leads. The present study provides supporting evidence that particular scalp channels are able to reflect the functional characteristics of their underlying cortical areas. Our data strengthen the clinical application of somatic-cortex-related leads for pain discrimination.

Original languageEnglish
Pages (from-to)460-469
Number of pages10
JournalJournal of Medical and Biological Engineering
Volume36
Issue number4
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

Bioelectric potentials
Electroencephalography
Lasers
Lead
Neuroimaging
Brain
Processing

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

@article{07577cca5478442bbcd3accafa31473e,
title = "Distinct Somatic Discrimination Reflected by Laser-Evoked Potentials Using Scalp EEG Leads",
abstract = "Discrimination is an important function in pain processing of the somatic cortex. The involvement of the somatic cortex has been studied using equivalent dipole analysis and neuroimaging, but the results are inconsistent. Scalp electroencephalography (EEG) can reflect functional changes of particular brain regions underneath a lead. However, the responses of EEG leads close to the somatic cortex in response to pain have not been systematically evaluated. The present study applied CO2 laser stimulation to the dorsum of the left hand. Laser-evoked potentials (LEPs) of C4, T3, and T4 leads and pain ratings in response to four stimulus intensities were analyzed. LEPs started earlier at the C4 and T4 leads. The onset latency and peak latency of LEPs for C4 and T4 leads were the same. Only 10 of 22 subjects (45 {\%}) presented equivalent current dipoles within the primary somatosensory or motor cortices. LEP amplitudes of these leads increased as stimulation intensity increased. The stimulus–response pattern of the C4 lead was highly correlated with pain rating. In contrast, an S-shaped stimulus–response curve was obtained for the T3 and T4 leads. The present study provides supporting evidence that particular scalp channels are able to reflect the functional characteristics of their underlying cortical areas. Our data strengthen the clinical application of somatic-cortex-related leads for pain discrimination.",
author = "Hsueh, {Jen Jui} and Chen, {Jia Jin Jason} and Shaw, {Fu Zen}",
year = "2016",
month = "8",
day = "1",
doi = "10.1007/s40846-016-0159-3",
language = "English",
volume = "36",
pages = "460--469",
journal = "Journal of Medical and Biological Engineering",
issn = "1609-0985",
publisher = "Biomedical Engineering Society",
number = "4",

}

TY - JOUR

T1 - Distinct Somatic Discrimination Reflected by Laser-Evoked Potentials Using Scalp EEG Leads

AU - Hsueh, Jen Jui

AU - Chen, Jia Jin Jason

AU - Shaw, Fu Zen

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Discrimination is an important function in pain processing of the somatic cortex. The involvement of the somatic cortex has been studied using equivalent dipole analysis and neuroimaging, but the results are inconsistent. Scalp electroencephalography (EEG) can reflect functional changes of particular brain regions underneath a lead. However, the responses of EEG leads close to the somatic cortex in response to pain have not been systematically evaluated. The present study applied CO2 laser stimulation to the dorsum of the left hand. Laser-evoked potentials (LEPs) of C4, T3, and T4 leads and pain ratings in response to four stimulus intensities were analyzed. LEPs started earlier at the C4 and T4 leads. The onset latency and peak latency of LEPs for C4 and T4 leads were the same. Only 10 of 22 subjects (45 %) presented equivalent current dipoles within the primary somatosensory or motor cortices. LEP amplitudes of these leads increased as stimulation intensity increased. The stimulus–response pattern of the C4 lead was highly correlated with pain rating. In contrast, an S-shaped stimulus–response curve was obtained for the T3 and T4 leads. The present study provides supporting evidence that particular scalp channels are able to reflect the functional characteristics of their underlying cortical areas. Our data strengthen the clinical application of somatic-cortex-related leads for pain discrimination.

AB - Discrimination is an important function in pain processing of the somatic cortex. The involvement of the somatic cortex has been studied using equivalent dipole analysis and neuroimaging, but the results are inconsistent. Scalp electroencephalography (EEG) can reflect functional changes of particular brain regions underneath a lead. However, the responses of EEG leads close to the somatic cortex in response to pain have not been systematically evaluated. The present study applied CO2 laser stimulation to the dorsum of the left hand. Laser-evoked potentials (LEPs) of C4, T3, and T4 leads and pain ratings in response to four stimulus intensities were analyzed. LEPs started earlier at the C4 and T4 leads. The onset latency and peak latency of LEPs for C4 and T4 leads were the same. Only 10 of 22 subjects (45 %) presented equivalent current dipoles within the primary somatosensory or motor cortices. LEP amplitudes of these leads increased as stimulation intensity increased. The stimulus–response pattern of the C4 lead was highly correlated with pain rating. In contrast, an S-shaped stimulus–response curve was obtained for the T3 and T4 leads. The present study provides supporting evidence that particular scalp channels are able to reflect the functional characteristics of their underlying cortical areas. Our data strengthen the clinical application of somatic-cortex-related leads for pain discrimination.

UR - http://www.scopus.com/inward/record.url?scp=84986905933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84986905933&partnerID=8YFLogxK

U2 - 10.1007/s40846-016-0159-3

DO - 10.1007/s40846-016-0159-3

M3 - Article

AN - SCOPUS:84986905933

VL - 36

SP - 460

EP - 469

JO - Journal of Medical and Biological Engineering

JF - Journal of Medical and Biological Engineering

SN - 1609-0985

IS - 4

ER -