Distribution and quantity of neuroendocrine markers in allergic rhinitis

Sheen-Yie Fang, Ching Liang Shen, Masuru Ohyama

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neuroendocrine components exist in the human nasal mucosa. However, the pathophysiological and neuroimmunological roles of the regulatory peptides in allergic rhinitis (AR) require further investigation. To analyse the functional morphology and quantify the tissue concentration of regulatory peptides in the nasal mucosa of AR subjects, human inferior turbinate mucosa specimens from 25 patients with AR, 20 patients with non-allergic rhinitis and 10 patients without any nasal diseases were investigated. Using immunohistochemistry and radioimmunoassays, we detected the presence, distribution and concentrations of various neuropeptides [vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), substance P (SP) and calcitonin gene-related peptide (CGRP)] and general neuroendocrine markers (neuron-specific enolase and chromogranin A). Quantitative analysis of the stained fibres and cells was performed using a graphic AutoCAD program. The presence and distribution of NPY, CGRP and SP nerve fibres and neuroendocrine cells were similar among the three subject groups. AR subjects had significantly higher tissue concentrations of VIP and SP. AR subjects had increased numbers of VIP fibres which predominantly innervated vessels. Thus, VIP and SP play important neuroimmunological roles in the pathogenesis of AR.

Original languageEnglish
Pages (from-to)398-403
Number of pages6
JournalActa Oto-Laryngologica
Volume118
Issue number3
DOIs
Publication statusPublished - 1998 Jun 25

Fingerprint

Vasoactive Intestinal Peptide
Substance P
Nasal Mucosa
Calcitonin Gene-Related Peptide
Neuropeptide Y
Nose Diseases
Chromogranin A
Turbinates
Neuroendocrine Cells
Peptides
Phosphopyruvate Hydratase
Rhinitis
Neuropeptides
Nerve Fibers
Radioimmunoassay
Allergic Rhinitis
Mucous Membrane
Immunohistochemistry
Neurons
peptide P

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Fang, Sheen-Yie ; Shen, Ching Liang ; Ohyama, Masuru. / Distribution and quantity of neuroendocrine markers in allergic rhinitis. In: Acta Oto-Laryngologica. 1998 ; Vol. 118, No. 3. pp. 398-403.
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Distribution and quantity of neuroendocrine markers in allergic rhinitis. / Fang, Sheen-Yie; Shen, Ching Liang; Ohyama, Masuru.

In: Acta Oto-Laryngologica, Vol. 118, No. 3, 25.06.1998, p. 398-403.

Research output: Contribution to journalArticle

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