Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study

Pei-Chun Hsieh, I-Hui Lee, Tzung Lieh Yeh, Kao-Ching Chen, Hui Chun Huang, Po-See Chen, Yen-Kuang Yang, Wei-Jen Yao, Ru-Band Lu, Nan-Tsing Chiu

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Abstract

Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume184
Issue number3
DOIs
Publication statusPublished - 2010 Dec 30

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Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Single-Photon Emission-Computed Tomography
Isotopes
Healthy Volunteers
Ligands
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

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abstract = "Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression.",
author = "Pei-Chun Hsieh and I-Hui Lee and Yeh, {Tzung Lieh} and Kao-Ching Chen and Huang, {Hui Chun} and Po-See Chen and Yen-Kuang Yang and Wei-Jen Yao and Ru-Band Lu and Nan-Tsing Chiu",
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AU - Yeh, Tzung Lieh

AU - Chen, Kao-Ching

AU - Huang, Hui Chun

AU - Chen, Po-See

AU - Yang, Yen-Kuang

AU - Yao, Wei-Jen

AU - Lu, Ru-Band

AU - Chiu, Nan-Tsing

PY - 2010/12/30

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N2 - Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression.

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