Dopamine transporter gene may be associated with bipolar disorder and its personality traits

Chang Chih Huang, Ru Band Lu, Che Hung Yen, Yi Wei Yeh, Han Wei Chou, Shin Chang Kuo, Chun Yen Chen, Chuan Chia Chang, Hsin An Chang, Pei Shen Ho, Chih Sung Liang, Serena Cheng, Mei Chen Shih, San Yuan Huang

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene (DAT1) in the pathogenesis of BPD remains unclear. The aims of this study were to assess 18 polymorphisms of the DAT1 gene to determine whether this gene is associated with BPD and whether it influences personality traits of patients with BPD. DAT1 polymorphisms were analyzed in 492 BPD (374 BPDI and 118 BPDII) patients and 436 controls. All participants were screened using the same assessment tool, and all met the criteria for BPD. The Tridimensional Personality Questionnaire was used to assess personality traits in both patients and controls. Several polymorphisms had a weak association with BPD, including rs2550948, rs2652511, and rs2975226 in allele distribution analysis (P < 0.05). Furthermore, the promoter G-A-C-G haplotype (rs6350-rs2975226-rs2652511-rs6413429) was over-represented in the BPD patients compared to the controls (P = 0.007). In personality assessment, the BPDII patients had the highest harm avoidance score, followed by the BPDI patients and controls (P = 3.7 × 10−32). In addition, a significant association between rs40184 and harm avoidance was found in the patients with BPD. The DAT1 promoter may be associated with vulnerabilities in BPD. The BPD patients had a higher rate of harm avoidance personality traits than the controls, and DAT1 variants may influence personality traits in patients with BPD.

Original languageEnglish
Pages (from-to)281-290
Number of pages10
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number4
Publication statusPublished - 2015 Jun 28

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)


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