Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence: A SPECT study

Yuan Hwa Chou, Wen Sheng Huang, Tung Ping Su, Ru Band Lu, Fang Jung Wan, Ying Kay Fu

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The purpose of this study was to examine the change of dopamine transporters (DAT) binding in methamphetamine (METH) abusers in a two-week period of abstinence and its association with cognitive function. Seven healthy subjects and seven METH abusers were recruited. At baseline conditions, the values of specific uptake ratio (SUR) of DAT binding measured by single photon emission computed tomography were lower in METH abusers than in controls. After a two-week period of abstinence, DAT binding was partially recovered and there were no statistic differences in SUR between METH abusers and controls. There was a borderline correlation between the changes of DAT binding in the right, but not the left, striatum and the %Error of Wisconsin Card Sorting Test. These findings indicate that DAT binding in METH abusers can be reversed in a short period of abstinence. The recovery of DAT binding was asymmetric and possibly parallel with the improvement of cognitive function.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalEuropean Neuropsychopharmacology
Volume17
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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