TY - JOUR
T1 - Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence
T2 - A SPECT study
AU - Chou, Yuan Hwa
AU - Huang, Wen Sheng
AU - Su, Tung Ping
AU - Lu, Ru Band
AU - Wan, Fang Jung
AU - Fu, Ying Kay
N1 - Funding Information:
The members of the Department of Nuclear Medicine, Tri-Service General Hospital are acknowledged. This study was supported by the National Science Council Taiwan (NSC 90-2314-B-409-002).
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The purpose of this study was to examine the change of dopamine transporters (DAT) binding in methamphetamine (METH) abusers in a two-week period of abstinence and its association with cognitive function. Seven healthy subjects and seven METH abusers were recruited. At baseline conditions, the values of specific uptake ratio (SUR) of DAT binding measured by single photon emission computed tomography were lower in METH abusers than in controls. After a two-week period of abstinence, DAT binding was partially recovered and there were no statistic differences in SUR between METH abusers and controls. There was a borderline correlation between the changes of DAT binding in the right, but not the left, striatum and the %Error of Wisconsin Card Sorting Test. These findings indicate that DAT binding in METH abusers can be reversed in a short period of abstinence. The recovery of DAT binding was asymmetric and possibly parallel with the improvement of cognitive function.
AB - The purpose of this study was to examine the change of dopamine transporters (DAT) binding in methamphetamine (METH) abusers in a two-week period of abstinence and its association with cognitive function. Seven healthy subjects and seven METH abusers were recruited. At baseline conditions, the values of specific uptake ratio (SUR) of DAT binding measured by single photon emission computed tomography were lower in METH abusers than in controls. After a two-week period of abstinence, DAT binding was partially recovered and there were no statistic differences in SUR between METH abusers and controls. There was a borderline correlation between the changes of DAT binding in the right, but not the left, striatum and the %Error of Wisconsin Card Sorting Test. These findings indicate that DAT binding in METH abusers can be reversed in a short period of abstinence. The recovery of DAT binding was asymmetric and possibly parallel with the improvement of cognitive function.
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U2 - 10.1016/j.euroneuro.2006.05.002
DO - 10.1016/j.euroneuro.2006.05.002
M3 - Article
C2 - 16842981
AN - SCOPUS:33751015400
SN - 0924-977X
VL - 17
SP - 46
EP - 52
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 1
ER -