Doppler spectral waveform parameters at neurovascular bundle vessels in patients with prostate biopsy

Yuh-Shyan Tsai, Yeong Chin Jou, Chia Hong Chen, Chien Chen Chang, Wen-Horng Yang, Jan Li Lai, Tzong Shin Tzai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction and Objectives: There is a need to improve prescreening determination of prostate cancer to better select patients who need biopsy. Such a strategy properly implemented, will decrease the number of negative biopsies for prostate cancer and in turn better balance the risks and morbidity for patients recommended for biopsy. The aim of study is to investigate Doppler spectral waveform parameters of neurovascular bundle (NVB) vessels and determine differences between benign and malignant pathologies. Patients and Methods: We performed a prospective analysis involving 292 patients who received prostate biopsy for elevated prostate-specific antigen (PSA) values or abnormal digital rectal examination, as well as 174 patients with symptomatic benign prostatic hyperplasia. Doppler spectral waveform (DSW) parameters (peak-systolic velocity [PSV], end-diastolic velocity [EDV], and resistive index [RI]) were measured at bilateral NVB vessels through Doppler transrectal ultrasound at the right lateral decubitus position, compared, and analyzed among patients with benign versus malignant histology for each side. Results: Overall, both PSV and EDV at malignant sides were significantly higher than those at benign sides, as well as lower RI (all p-values <0.05, unpaired t-test). In subgroup analysis with 93 patients of serum PSA between 10 and 20 ng/mL and 56 patients with one-side malignancy, higher EDV and lower RI were significantly associated with malignancies (all p<0.05). The values of PSV and EDV rather than RI might be influenced by the patients' position and RI by the prostate volume. Conclusions: In this study, DSW parameters (mainly EDV and RI) at NVB vessels were significantly associated with prostate cancer, particularly in patients with serum PSA of 10-20 ng/mL. It should be in caution that the patients' position and prostate volume may influence the Doppler signal as demonstrated in the current study. These findings can provide more diagnostic information before prostate biopsy.

Original languageEnglish
Pages (from-to)364-370
Number of pages7
JournalJournal of Endourology
Volume28
Issue number3
DOIs
Publication statusPublished - 2014 Mar 1

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Prostate
Biopsy
Prostate-Specific Antigen
Prostatic Neoplasms
Digital Rectal Examination
Doppler Ultrasonography
Prostatic Hyperplasia
Serum
Neoplasms
Histology
Pathology
Morbidity

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Tsai, Yuh-Shyan ; Jou, Yeong Chin ; Chen, Chia Hong ; Chang, Chien Chen ; Yang, Wen-Horng ; Lai, Jan Li ; Tzai, Tzong Shin. / Doppler spectral waveform parameters at neurovascular bundle vessels in patients with prostate biopsy. In: Journal of Endourology. 2014 ; Vol. 28, No. 3. pp. 364-370.
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abstract = "Introduction and Objectives: There is a need to improve prescreening determination of prostate cancer to better select patients who need biopsy. Such a strategy properly implemented, will decrease the number of negative biopsies for prostate cancer and in turn better balance the risks and morbidity for patients recommended for biopsy. The aim of study is to investigate Doppler spectral waveform parameters of neurovascular bundle (NVB) vessels and determine differences between benign and malignant pathologies. Patients and Methods: We performed a prospective analysis involving 292 patients who received prostate biopsy for elevated prostate-specific antigen (PSA) values or abnormal digital rectal examination, as well as 174 patients with symptomatic benign prostatic hyperplasia. Doppler spectral waveform (DSW) parameters (peak-systolic velocity [PSV], end-diastolic velocity [EDV], and resistive index [RI]) were measured at bilateral NVB vessels through Doppler transrectal ultrasound at the right lateral decubitus position, compared, and analyzed among patients with benign versus malignant histology for each side. Results: Overall, both PSV and EDV at malignant sides were significantly higher than those at benign sides, as well as lower RI (all p-values <0.05, unpaired t-test). In subgroup analysis with 93 patients of serum PSA between 10 and 20 ng/mL and 56 patients with one-side malignancy, higher EDV and lower RI were significantly associated with malignancies (all p<0.05). The values of PSV and EDV rather than RI might be influenced by the patients' position and RI by the prostate volume. Conclusions: In this study, DSW parameters (mainly EDV and RI) at NVB vessels were significantly associated with prostate cancer, particularly in patients with serum PSA of 10-20 ng/mL. It should be in caution that the patients' position and prostate volume may influence the Doppler signal as demonstrated in the current study. These findings can provide more diagnostic information before prostate biopsy.",
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Doppler spectral waveform parameters at neurovascular bundle vessels in patients with prostate biopsy. / Tsai, Yuh-Shyan; Jou, Yeong Chin; Chen, Chia Hong; Chang, Chien Chen; Yang, Wen-Horng; Lai, Jan Li; Tzai, Tzong Shin.

In: Journal of Endourology, Vol. 28, No. 3, 01.03.2014, p. 364-370.

Research output: Contribution to journalArticle

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