Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of nigrofomes melanoporus and their cytotoxicity

Hsiu Hui Chan, Shin Hun Juang, Tran Dinh Thang, Min Yu Chen, Ping Chung Kuo, Mei Lin Yang, Nguyen Thi Ngan, Nguyen Ngoc Linh, Tian Shung Wu

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Abstract

Two new drimane-type compounds, nigrofomins A (1) and B (2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A (1) and B (2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC 50 values in the range of 99.44-246.32 μM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G 0/G 1 phase.

Original languageEnglish
Pages (from-to)737-739
Number of pages3
JournalPlanta Medica
Volume78
Issue number7
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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