Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery

Wen-Chung Wu, Chi Ming Huang, Po Wen Liao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

For this study, we prepared a new type of drug carrier with the characteristics of stimuli-responsive transition and tumor-specific recognition through the co-assembly of two series of amphiphilic block copolymers, poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N- methacryloyl caproic acid] and poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N-(2-(methacrylamido)ethyl) folatic amide]. The pH-dependent thermal transition and the content of the targeting ligands of the mixed polymeric micelles are well correlated with the chemical structures and compositions of these two copolymers. Doxorubicin-loaded mixed polymeric micelles are stable at body temperature in the neutral condition for prolonged circulation in blood vessels, and demonstrated rapid drug release at acidic pH levels. The cumulative drug release profiles showed a relatively slow release at pH 7.4, and a quick release of 85% in 3 h at pH 5.3. The cytotoxicity tests against FA-positive (HeLa) and FA-negative (HT-29) tumor cell lines suggest that this mixed polymeric micelle system has potential merits as a controlled and targeted drug delivery system.

Original languageEnglish
Pages (from-to)82-90
Number of pages9
JournalReactive and Functional Polymers
Volume81
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Controlled drug delivery
Micelles
Folic Acid
drug
Glycols
Tumors
tumor
Pharmaceutical Preparations
Drug Carriers
Blood vessels
Cytotoxicity
Amides
HT29 Cells
Doxorubicin
Block copolymers
body temperature
Drug Delivery Systems
Copolymers
Tumor Cell Line
Body Temperature

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Biochemistry
  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

@article{2fcb8b0d291243b6ad4d444dda76e35b,
title = "Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery",
abstract = "For this study, we prepared a new type of drug carrier with the characteristics of stimuli-responsive transition and tumor-specific recognition through the co-assembly of two series of amphiphilic block copolymers, poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N- methacryloyl caproic acid] and poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N-(2-(methacrylamido)ethyl) folatic amide]. The pH-dependent thermal transition and the content of the targeting ligands of the mixed polymeric micelles are well correlated with the chemical structures and compositions of these two copolymers. Doxorubicin-loaded mixed polymeric micelles are stable at body temperature in the neutral condition for prolonged circulation in blood vessels, and demonstrated rapid drug release at acidic pH levels. The cumulative drug release profiles showed a relatively slow release at pH 7.4, and a quick release of 85{\%} in 3 h at pH 5.3. The cytotoxicity tests against FA-positive (HeLa) and FA-negative (HT-29) tumor cell lines suggest that this mixed polymeric micelle system has potential merits as a controlled and targeted drug delivery system.",
author = "Wen-Chung Wu and Huang, {Chi Ming} and Liao, {Po Wen}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.reactfunctpolym.2014.05.003",
language = "English",
volume = "81",
pages = "82--90",
journal = "Reactive and Functional Polymers",
issn = "1381-5148",
publisher = "Elsevier",
number = "1",

}

Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery. / Wu, Wen-Chung; Huang, Chi Ming; Liao, Po Wen.

In: Reactive and Functional Polymers, Vol. 81, No. 1, 01.01.2014, p. 82-90.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery

AU - Wu, Wen-Chung

AU - Huang, Chi Ming

AU - Liao, Po Wen

PY - 2014/1/1

Y1 - 2014/1/1

N2 - For this study, we prepared a new type of drug carrier with the characteristics of stimuli-responsive transition and tumor-specific recognition through the co-assembly of two series of amphiphilic block copolymers, poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N- methacryloyl caproic acid] and poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N-(2-(methacrylamido)ethyl) folatic amide]. The pH-dependent thermal transition and the content of the targeting ligands of the mixed polymeric micelles are well correlated with the chemical structures and compositions of these two copolymers. Doxorubicin-loaded mixed polymeric micelles are stable at body temperature in the neutral condition for prolonged circulation in blood vessels, and demonstrated rapid drug release at acidic pH levels. The cumulative drug release profiles showed a relatively slow release at pH 7.4, and a quick release of 85% in 3 h at pH 5.3. The cytotoxicity tests against FA-positive (HeLa) and FA-negative (HT-29) tumor cell lines suggest that this mixed polymeric micelle system has potential merits as a controlled and targeted drug delivery system.

AB - For this study, we prepared a new type of drug carrier with the characteristics of stimuli-responsive transition and tumor-specific recognition through the co-assembly of two series of amphiphilic block copolymers, poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N- methacryloyl caproic acid] and poly(ε-caprolactone)-b-poly[triethylene glycol methacrylate-co-N-(2-(methacrylamido)ethyl) folatic amide]. The pH-dependent thermal transition and the content of the targeting ligands of the mixed polymeric micelles are well correlated with the chemical structures and compositions of these two copolymers. Doxorubicin-loaded mixed polymeric micelles are stable at body temperature in the neutral condition for prolonged circulation in blood vessels, and demonstrated rapid drug release at acidic pH levels. The cumulative drug release profiles showed a relatively slow release at pH 7.4, and a quick release of 85% in 3 h at pH 5.3. The cytotoxicity tests against FA-positive (HeLa) and FA-negative (HT-29) tumor cell lines suggest that this mixed polymeric micelle system has potential merits as a controlled and targeted drug delivery system.

UR - http://www.scopus.com/inward/record.url?scp=84902161340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902161340&partnerID=8YFLogxK

U2 - 10.1016/j.reactfunctpolym.2014.05.003

DO - 10.1016/j.reactfunctpolym.2014.05.003

M3 - Article

VL - 81

SP - 82

EP - 90

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

SN - 1381-5148

IS - 1

ER -