Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

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Abstract

Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

Original languageEnglish
Pages (from-to)542-547
Number of pages6
JournalCancer Investigation
Volume29
Issue number8
DOIs
Publication statusPublished - 2011 Oct 1

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Colorectal Neoplasms
Membrane Proteins
Liver
Neoplasm Metastasis
Colonic Neoplasms
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients",
abstract = "Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48{\%} of patients with early-stage CRC versus only 33{\%} of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.",
author = "Peng-Chan Lin and Shao-Chieh Lin and Chung-Ta Lee and Yih-Jyh Lin and Jenq-Chang Lee",
year = "2011",
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doi = "10.3109/07357907.2011.606251",
language = "English",
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T1 - Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

AU - Lin, Peng-Chan

AU - Lin, Shao-Chieh

AU - Lee, Chung-Ta

AU - Lin, Yih-Jyh

AU - Lee, Jenq-Chang

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

AB - Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

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