Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

Peng Chan Lin; Shao Chieh Lin; Chung Ta Lee; Yih Jyh Lin; Jenq Chang Lee

doi:10.3109/07357907.2011.606251

Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

Peng Chan Lin
, Shao Chieh Lin
, Chung Ta Lee
, Yih Jyh Lin
, Jenq Chang Lee

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

Original language	English
Pages (from-to)	542-547
Number of pages	6
Journal	Cancer Investigation
Volume	29
Issue number	8
DOIs	https://doi.org/10.3109/07357907.2011.606251
Publication status	Published - 2011 Oct

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.3109/07357907.2011.606251

Cite this

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title = "Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients",

abstract = "Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48\% of patients with early-stage CRC versus only 33\% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.",

author = "Lin, \{Peng Chan\} and Lin, \{Shao Chieh\} and Lee, \{Chung Ta\} and Lin, \{Yih Jyh\} and Lee, \{Jenq Chang\}",

note = "Funding Information: This project was supported by grants of the National Cheng Kung University Medical Institute and Hospital, Tainan, Taiwan.",

year = "2011",

month = oct,

doi = "10.3109/07357907.2011.606251",

language = "English",

volume = "29",

pages = "542--547",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor \& Francis Group LLC Philadelphia",

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}

TY - JOUR

T1 - Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

AU - Lin, Peng Chan

AU - Lin, Shao Chieh

AU - Lee, Chung Ta

AU - Lin, Yih Jyh

AU - Lee, Jenq Chang

N1 - Funding Information: This project was supported by grants of the National Cheng Kung University Medical Institute and Hospital, Tainan, Taiwan.

PY - 2011/10

Y1 - 2011/10

N2 - Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

AB - Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

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UR - https://www.scopus.com/pages/publications/80052754201#tab=citedBy

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DO - 10.3109/07357907.2011.606251

M3 - Article

C2 - 21913879

AN - SCOPUS:80052754201

SN - 0735-7907

VL - 29

SP - 542

EP - 547

JO - Cancer Investigation

JF - Cancer Investigation

IS - 8

ER -

Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

Abstract

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