Dynamics of dielectrophoretic field-flow fractionation (dep-fff) based micro sorter for cell separation

Tzong-Shyng Leu, Chih Yuan Weng

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dielectrophoretic Field-Flow Fractionation (DEP-FFF) is a technique that selects particles of interest from a mixture of many samples. Conventional DEP-FFF technique used DEP force to levitate particles to different heights according to their dielectric properties. Levitated particles are then separated by their velocity difference in a microchannel. Numerical simulation and experimental results found that particles become wavy trajectory when the ratio of levitation height (hp) and average of electrode width and spacing (d) is below 0.6 (hp/d<0.6). In the mean time, sorted particles disperse randomly in Y-direction, too. The wavy trajectory and random distribution cause cell separation imprecisely. A novel MEMS-fabricated DEP-FFF based micro sorters is designed to improve these problems. The experimental results show that the particles can be levitated to a constant height and focus into a single particle stream along the centerline in the new micro sorter design. One can conclude that the new design leads to better cell separation in a DEP-FFF based micro sorter.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalModern Physics Letters B
Volume23
Issue number3
DOIs
Publication statusPublished - 2009 Jan 30

Fingerprint

fractionation
flow distribution
cells
trajectories
levitation
microchannels
statistical distributions
microelectromechanical systems
dielectric properties
spacing
electrodes
causes
simulation

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics

Cite this

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Dynamics of dielectrophoretic field-flow fractionation (dep-fff) based micro sorter for cell separation. / Leu, Tzong-Shyng; Weng, Chih Yuan.

In: Modern Physics Letters B, Vol. 23, No. 3, 30.01.2009, p. 389-392.

Research output: Contribution to journalArticle

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