Dynamics of single polymers in a stagnation flow induced by electrokinetics

Yi-Je Juang, S. Wang, X. Hu, L. J. Lee

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The elongational flow field that could be generated by using electrokinetic forces in a microscale cross-channel was demonstrated. Electric-field-induced DNA stretching was investigated by several groups, where the DNA molecules were either tethered on a surface or suspended inside a straight channel filled with 'sieving' linear polymer molecules to induce DNA stretching. The initial conformation and the residence time of the DNA molecules shows that the flow field is fairly homogeneous and two dimensional. The results show that the use of coarse-grain molecular modeling is able to qualitatively simulate the conformational changes of DNA molecules.

Original languageEnglish
Article number268105
JournalPhysical review letters
Volume93
Issue number26 I
DOIs
Publication statusPublished - 2004 Dec 31

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stagnation flow
electrokinetics
deoxyribonucleic acid
polymers
molecules
flow distribution
microbalances
electric fields

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

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abstract = "The elongational flow field that could be generated by using electrokinetic forces in a microscale cross-channel was demonstrated. Electric-field-induced DNA stretching was investigated by several groups, where the DNA molecules were either tethered on a surface or suspended inside a straight channel filled with 'sieving' linear polymer molecules to induce DNA stretching. The initial conformation and the residence time of the DNA molecules shows that the flow field is fairly homogeneous and two dimensional. The results show that the use of coarse-grain molecular modeling is able to qualitatively simulate the conformational changes of DNA molecules.",
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Dynamics of single polymers in a stagnation flow induced by electrokinetics. / Juang, Yi-Je; Wang, S.; Hu, X.; Lee, L. J.

In: Physical review letters, Vol. 93, No. 26 I, 268105, 31.12.2004.

Research output: Contribution to journalArticle

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