Dysfunction screening in experimental arteriovenous grafts for hemodialysis using inflow and outflow hemodynamic game analysis

Wei Ling Chen, Chung Dann Kan, Chia Hung Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hemodialysis access stenosis leading to dysfunction occurs at the venous anastomsis site or the outflow vein. Information from the inflow stenosis, such as blood pressure, flow velocity, and flow resistance increases, allows dysfunction screening from early clots and thrombosis to the progress of outflow stenosis. To prevent access complications, such as inflow / outflow stenosis and steal syndrome, this study proposes the dysfunction screening in experimental arteriovenous grafts (AVGs) for hemodialysis using inflow and outflow hemodynamic game analysis. In physical examinations, a stenosis limits flow volume, and then the pressure at a stenotic locus rapidly falls between inflow and outflow. Therefore, pressure drop and flow resistance can be estimated based on variations in flow volume. The quantitative differences can be applied to evaluate the risk of access dysfunction, in terms of the degree of stenosis (DOS). With the differential pressure sensors, the measured pressure drop, AP, is used to estimate the injection velocity, Vinj, and resistance (Res) index through an experimental AVG. A cooperative game (CG) based decision-making model is then utilized to evaluate the risk of an AVG dysfunction. The proposed model is implemented with the LabVIEW graphical programming. For an equivalent human circulation system, a total of 72 measurements were made at each inflow and outflow site, at locations ± lDa, l = 5,10,17 and Da = 0.635cm. At least 6 measurements were made at each location under various DOS with varying 50% to 95%. The findings indicate that the proposed measurement method and decision-making model can be carried out in practical examinations during hemodialysis.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, 2015
EditorsDavid A. Jaffray
PublisherSpringer Verlag
Pages309-317
Number of pages9
ISBN (Print)9783319193878
DOIs
Publication statusPublished - 2015 Jan 1
EventWorld Congress on Medical Physics and Biomedical Engineering, 2015 - Toronto, Canada
Duration: 2015 Jun 72015 Jun 12

Publication series

NameIFMBE Proceedings
Volume51
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering, 2015
CountryCanada
CityToronto
Period15-06-0715-06-12

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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