Dysregulation of MicroRNAs in cancer

Pai-Sheng Chen, Jen Liang Su, Mien Chie Hung

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the functions of their targets. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer, and there is mounting evidence demonstrating several misguided mechanisms that cause miRNA dysregulation. In this review, we summarize the key functions of miRNAs in cancer, especially those affecting tumor metastasis and drug resistance. Moreover, the mechanisms leading to dysregulation of miRNAs, including genomic abnormalities, DNA/histone modifications, transcriptional regulation, abnormal biogenesis, and interaction between miRNAs, are also discussed.

Original languageEnglish
Article number90
JournalJournal of biomedical science
Volume19
Issue number1
DOIs
Publication statusPublished - 2012 Oct 19

Fingerprint

MicroRNAs
Neoplasms
Tumors
Histone Code
Bioactivity
Mountings
Oncogenes
Drug Resistance
Histones
Disease Progression
Throughput
Neoplasm Metastasis
DNA
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

Cite this

Chen, Pai-Sheng ; Su, Jen Liang ; Hung, Mien Chie. / Dysregulation of MicroRNAs in cancer. In: Journal of biomedical science. 2012 ; Vol. 19, No. 1.
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Dysregulation of MicroRNAs in cancer. / Chen, Pai-Sheng; Su, Jen Liang; Hung, Mien Chie.

In: Journal of biomedical science, Vol. 19, No. 1, 90, 19.10.2012.

Research output: Contribution to journalReview article

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