TY - JOUR
T1 - Dysregulation of MicroRNAs in cancer
AU - Chen, Pai Sheng
AU - Su, Jen Liang
AU - Hung, Mien Chie
N1 - Funding Information:
This work was supported by grants from the U.S. National Institutes of Health (RO1 CA109311 and PO1 CA099031), National Science Council, Taiwan (NSC 99-2314-B-039-002-MY3); National Health Research Institutes grants from Taiwan (NHRI-EX101-10033BI and NHRI-EX100-9712BC); grants from China Medical University (CMU99-TC-22 and CMU100-S-22); and The University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund (DMR-101-115). We apologize to the many investigators whose important studies could not be cited directly here owing to space limitation.
PY - 2012
Y1 - 2012
N2 - MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the functions of their targets. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer, and there is mounting evidence demonstrating several misguided mechanisms that cause miRNA dysregulation. In this review, we summarize the key functions of miRNAs in cancer, especially those affecting tumor metastasis and drug resistance. Moreover, the mechanisms leading to dysregulation of miRNAs, including genomic abnormalities, DNA/histone modifications, transcriptional regulation, abnormal biogenesis, and interaction between miRNAs, are also discussed.
AB - MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the functions of their targets. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer, and there is mounting evidence demonstrating several misguided mechanisms that cause miRNA dysregulation. In this review, we summarize the key functions of miRNAs in cancer, especially those affecting tumor metastasis and drug resistance. Moreover, the mechanisms leading to dysregulation of miRNAs, including genomic abnormalities, DNA/histone modifications, transcriptional regulation, abnormal biogenesis, and interaction between miRNAs, are also discussed.
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U2 - 10.1186/1423-0127-19-90
DO - 10.1186/1423-0127-19-90
M3 - Review article
C2 - 23075324
AN - SCOPUS:84867441742
SN - 1021-7770
VL - 19
JO - Journal of biomedical science
JF - Journal of biomedical science
IS - 1
M1 - 90
ER -