Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

Shih Chieh Lin, Chung Yang Kao, Hui Ju Lee, Chad J. Creighton, Michael M. Ittmann, Shaw Jenq Tsai, Sophia Y. Tsai, Ming Jer Tsai

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Although early detection and treatment of prostate cancer (PCa) improves outcomes, many patients still die of metastatic PCa. Here, we report that metastatic PCa exhibits reduced levels of the microRNAsmiR-101 and miR-27a. These micro-RNAs (miRNAs) negatively regulate cell invasion and inhibit the expression of FOXM1 and CENPF, two master regulators of metastasis in PCa. Interestingly, the repression of FOXM1 and CENPF by these miRNAs occurs through COUP-TFII, a member of the orphan nuclear receptors family. Loss of miR-101 positively correlates with the increase of COUP-TFII-FOXM1-CENPF activity in clinical PCa data sets, implicating clinical relevance of such regulation. Further studies show that COUP-TFII is a critical factor controlling metastatic gene networks to promote PCa metastasis. Most importantly, this miRNA-COUP-TFII-FOXM1-CENPF regulatory axis is also involved in the development of enzalutaminde resistance. Taken together, our findings highlight the contribution of specific miRNAs through the regulation of the COUP-TFII-FOXM1-CENPF cascade in PCa metastasis and drug resistance.

Original languageEnglish
Article number11418
JournalNature communications
Volume7
DOIs
Publication statusPublished - 2016 Apr 25

Fingerprint

metastasis
MicroRNAs
Prostatic Neoplasms
cancer
Neoplasm Metastasis
Orphan Nuclear Receptors
Genes
Gene Regulatory Networks
regulators
Nuclear Family
Drug Resistance
genes
Pharmaceutical Preparations
cascades
drugs
cells

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Lin, Shih Chieh ; Kao, Chung Yang ; Lee, Hui Ju ; Creighton, Chad J. ; Ittmann, Michael M. ; Tsai, Shaw Jenq ; Tsai, Sophia Y. ; Tsai, Ming Jer. / Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. In: Nature communications. 2016 ; Vol. 7.
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abstract = "Although early detection and treatment of prostate cancer (PCa) improves outcomes, many patients still die of metastatic PCa. Here, we report that metastatic PCa exhibits reduced levels of the microRNAsmiR-101 and miR-27a. These micro-RNAs (miRNAs) negatively regulate cell invasion and inhibit the expression of FOXM1 and CENPF, two master regulators of metastasis in PCa. Interestingly, the repression of FOXM1 and CENPF by these miRNAs occurs through COUP-TFII, a member of the orphan nuclear receptors family. Loss of miR-101 positively correlates with the increase of COUP-TFII-FOXM1-CENPF activity in clinical PCa data sets, implicating clinical relevance of such regulation. Further studies show that COUP-TFII is a critical factor controlling metastatic gene networks to promote PCa metastasis. Most importantly, this miRNA-COUP-TFII-FOXM1-CENPF regulatory axis is also involved in the development of enzalutaminde resistance. Taken together, our findings highlight the contribution of specific miRNAs through the regulation of the COUP-TFII-FOXM1-CENPF cascade in PCa metastasis and drug resistance.",
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Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. / Lin, Shih Chieh; Kao, Chung Yang; Lee, Hui Ju; Creighton, Chad J.; Ittmann, Michael M.; Tsai, Shaw Jenq; Tsai, Sophia Y.; Tsai, Ming Jer.

In: Nature communications, Vol. 7, 11418, 25.04.2016.

Research output: Contribution to journalArticle

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