TY - JOUR
T1 - Early cataract detection by dynamic light scattering with sparse Bayesian learning
AU - Nyeo, Su Long
AU - Ansari, Rafat R.
N1 - Funding Information:
Part of this work was carried out at the School of Health Information Sciences of the University of Texas Health Science Center at Houston while Dr Nyeo was a visiting Professor and Dr Ansari was a full Professor at UTHSC. The authors are very grateful to Dr J. S. Zigler Jr. for providing the lens samples. Dr Nyeo would like to acknowledge the financial support from the National Science Council of the Republic of China under the Contract No. NSC-97-2112-M-006-006.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2009/7
Y1 - 2009/7
N2 - Dynamic light scattering (DLS) is a promising technique for early cataract detection and for studying cataractogenesis. A novel probabilistic analysis tool, the sparse Bayesian learning (SBL) algorithm, is described for reconstructing the most-probable size distribution of α-crystallin and their aggregates in an ocular lens from the DLS data. The performance of the algorithm is evaluated by analyzing simulated correlation data from known distributions and DLS data from the ocular lenses of a fetal calf, a Rhesus monkey, and a man, so as to establish the required efficiency of the SBL algorithm for clinical studies.
AB - Dynamic light scattering (DLS) is a promising technique for early cataract detection and for studying cataractogenesis. A novel probabilistic analysis tool, the sparse Bayesian learning (SBL) algorithm, is described for reconstructing the most-probable size distribution of α-crystallin and their aggregates in an ocular lens from the DLS data. The performance of the algorithm is evaluated by analyzing simulated correlation data from known distributions and DLS data from the ocular lenses of a fetal calf, a Rhesus monkey, and a man, so as to establish the required efficiency of the SBL algorithm for clinical studies.
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U2 - 10.1142/S1793545809000632
DO - 10.1142/S1793545809000632
M3 - Article
AN - SCOPUS:79251599348
SN - 1793-5458
VL - 2
SP - 303
EP - 313
JO - Journal of Innovative Optical Health Sciences
JF - Journal of Innovative Optical Health Sciences
IS - 3
ER -