Early dexamethasone treatment exacerbates enterovirus 71 infection in mice

Fang Hsiu Shen, Ting Jing Shen, Tung Miao Chang, Ih Jen Su, Shun-hua Chen

Research output: Contribution to journalArticle

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Abstract

Enterovirus 71 (EV71) infection can induce encephalitis. Overt immune responses is suspected to cause severe symptoms, so anti-inflammatory agents, corticosteroids have been recommended for treatment. However, one clinical study reported that treatment with glucocorticoids, dexamethasone (Dex) exacerbates disease severity. Here we investigated Dex treatment on EV71 infection using the murine model and found that both long-term (14-day) and short-term (4-day) Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice. Dex treatment starting from 4 or 8 days postinfection did not affect mouse mortality and disease severity. Early Dex treatment starting from 1 day postinfection caused atrophy and enhanced apoptosis in lymphoid organs to decrease the numbers of lymphocytes (CD4+ T cells, CD8+ T cells, and CD19+ B cells) and to increase viral loads in infected tissues of mice. Our results demonstrate that Dex treatment has no beneficial effect on EV71 infection.

Original languageEnglish
Pages (from-to)218-227
Number of pages10
JournalVirology
Volume464-465
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Enterovirus Infections
Dexamethasone
T-Lymphocytes
Mortality
Lymphocyte Count
Encephalitis
Viral Load
Glucocorticoids
Atrophy
Adrenal Cortex Hormones
B-Lymphocytes
Anti-Inflammatory Agents
Apoptosis

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Shen, Fang Hsiu ; Shen, Ting Jing ; Chang, Tung Miao ; Su, Ih Jen ; Chen, Shun-hua. / Early dexamethasone treatment exacerbates enterovirus 71 infection in mice. In: Virology. 2014 ; Vol. 464-465, No. 1. pp. 218-227.
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abstract = "Enterovirus 71 (EV71) infection can induce encephalitis. Overt immune responses is suspected to cause severe symptoms, so anti-inflammatory agents, corticosteroids have been recommended for treatment. However, one clinical study reported that treatment with glucocorticoids, dexamethasone (Dex) exacerbates disease severity. Here we investigated Dex treatment on EV71 infection using the murine model and found that both long-term (14-day) and short-term (4-day) Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice. Dex treatment starting from 4 or 8 days postinfection did not affect mouse mortality and disease severity. Early Dex treatment starting from 1 day postinfection caused atrophy and enhanced apoptosis in lymphoid organs to decrease the numbers of lymphocytes (CD4+ T cells, CD8+ T cells, and CD19+ B cells) and to increase viral loads in infected tissues of mice. Our results demonstrate that Dex treatment has no beneficial effect on EV71 infection.",
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Early dexamethasone treatment exacerbates enterovirus 71 infection in mice. / Shen, Fang Hsiu; Shen, Ting Jing; Chang, Tung Miao; Su, Ih Jen; Chen, Shun-hua.

In: Virology, Vol. 464-465, No. 1, 01.01.2014, p. 218-227.

Research output: Contribution to journalArticle

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AB - Enterovirus 71 (EV71) infection can induce encephalitis. Overt immune responses is suspected to cause severe symptoms, so anti-inflammatory agents, corticosteroids have been recommended for treatment. However, one clinical study reported that treatment with glucocorticoids, dexamethasone (Dex) exacerbates disease severity. Here we investigated Dex treatment on EV71 infection using the murine model and found that both long-term (14-day) and short-term (4-day) Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice. Dex treatment starting from 4 or 8 days postinfection did not affect mouse mortality and disease severity. Early Dex treatment starting from 1 day postinfection caused atrophy and enhanced apoptosis in lymphoid organs to decrease the numbers of lymphocytes (CD4+ T cells, CD8+ T cells, and CD19+ B cells) and to increase viral loads in infected tissues of mice. Our results demonstrate that Dex treatment has no beneficial effect on EV71 infection.

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