Early experimental results of colorectal carcinoma chemotherapeutics by liposomal curcuminoids

Ming Jenn Chen, Yu Wen Lin, Ya-Min Cheng, June Fu Wu, Yi Chiang Hsu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Curcuminoids had shown anti-proliferation and induce the apoptosis in many cancer cells. It was chosen as the model drug and liposome, a biocompatible and biodegradable carrier was used (liposomal curcuminoids; LPC). The technique was also investigated for the possibility of facilitating the anti-tumor activity of LPC in colorectal cancer (CRC). In-vitro permeation studies in fresh pig colon mucosa; we found that reduced the cumulative amount and flux of LPC. There are 7.8 folds decreasing which compared to the curcuminoids treatment without liposomal encapsulation. Summary the results show that the liposomal encapsulation could enhance and prolong the cytotoxicity of curcuminoids through possibly increase the cellular uptake of curcuminoids in colorectal cancer cell (CRC) lines (CP1 to CP5). Through the use of LPC, the transmucosa drug delivery system (DDS) of liposome encapsulation to the CRC cancer therapy could be made possible.

Original languageEnglish
Pages (from-to)1445-1456
Number of pages12
JournalDigest Journal of Nanomaterials and Biostructures
Volume6
Issue number3
Publication statusPublished - 2011 Oct 12

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Early experimental results of colorectal carcinoma chemotherapeutics by liposomal curcuminoids'. Together they form a unique fingerprint.

Cite this