Abstract
Objectives: We evaluated electrophysiological benefits of reperfusion following ischemic stroke. Methods: Rats received either transient proximal occlusion of the right middle cerebral artery for 30 (Group I, n=8) or 90 minutes (Group II, n=8) or permanent thermocoagulation of the distal right middle cerebral artery (Group III, n=6). Neurobehavioral outcome and somatosensory evoked potentials (SSEPs) were examined before and at 7 days after the onset of brain ischemia. Brain infarction was assessed after the rats were euthanized. Results: Before ischemia, stable SSEPs were consistently recorded. At 7 days post-insult, Group III (permanent occlusion) had the greatest reduction in the SSEPs recorded ipsilaterally and contralaterally. Groups I and II (transient ischemic groups) also had depressant SSEPs recorded from the ipsilateral ischemic and the contralateral intact brain (electrophysiological diaschisis). However, prolonged ischemia resulted in greater brain infarction and increased neurological deficits in addition to greater reductions in the ipsilateral and the contralateral SSEPs. Conclusion: Early reperfusion facilitates the electrophysiological recovery in both ipsilateral lesional and the contralateral intact brain, which may be closely relevant to post-injury brain rewiring. We also demonstrated that contralateral electrophysiological diaschisis could be greatly reversed by early reperfusion and is independent of the lesion size of striatum.
| Original language | English |
|---|---|
| Pages (from-to) | 828-834 |
| Number of pages | 7 |
| Journal | Neurological Research |
| Volume | 32 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2010 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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Early reperfusion improves the recovery of contralateral electrophysiological diaschisis following focal cerebral ischemia in rats. / Hong, Yu-Chang; Chou, Ya Shuan; Chang, Chih-Han; Lin, Hsiao Wen; Chen, Hung Yi; Chen, Tsung Ying; Tai, Shih-Huang; Lee, E-Jian.
In: Neurological Research, Vol. 32, No. 8, 01.10.2010, p. 828-834.Research output: Contribution to journal › Article
TY - JOUR
T1 - Early reperfusion improves the recovery of contralateral electrophysiological diaschisis following focal cerebral ischemia in rats
AU - Hong, Yu-Chang
AU - Chou, Ya Shuan
AU - Chang, Chih-Han
AU - Lin, Hsiao Wen
AU - Chen, Hung Yi
AU - Chen, Tsung Ying
AU - Tai, Shih-Huang
AU - Lee, E-Jian
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Objectives: We evaluated electrophysiological benefits of reperfusion following ischemic stroke. Methods: Rats received either transient proximal occlusion of the right middle cerebral artery for 30 (Group I, n=8) or 90 minutes (Group II, n=8) or permanent thermocoagulation of the distal right middle cerebral artery (Group III, n=6). Neurobehavioral outcome and somatosensory evoked potentials (SSEPs) were examined before and at 7 days after the onset of brain ischemia. Brain infarction was assessed after the rats were euthanized. Results: Before ischemia, stable SSEPs were consistently recorded. At 7 days post-insult, Group III (permanent occlusion) had the greatest reduction in the SSEPs recorded ipsilaterally and contralaterally. Groups I and II (transient ischemic groups) also had depressant SSEPs recorded from the ipsilateral ischemic and the contralateral intact brain (electrophysiological diaschisis). However, prolonged ischemia resulted in greater brain infarction and increased neurological deficits in addition to greater reductions in the ipsilateral and the contralateral SSEPs. Conclusion: Early reperfusion facilitates the electrophysiological recovery in both ipsilateral lesional and the contralateral intact brain, which may be closely relevant to post-injury brain rewiring. We also demonstrated that contralateral electrophysiological diaschisis could be greatly reversed by early reperfusion and is independent of the lesion size of striatum.
AB - Objectives: We evaluated electrophysiological benefits of reperfusion following ischemic stroke. Methods: Rats received either transient proximal occlusion of the right middle cerebral artery for 30 (Group I, n=8) or 90 minutes (Group II, n=8) or permanent thermocoagulation of the distal right middle cerebral artery (Group III, n=6). Neurobehavioral outcome and somatosensory evoked potentials (SSEPs) were examined before and at 7 days after the onset of brain ischemia. Brain infarction was assessed after the rats were euthanized. Results: Before ischemia, stable SSEPs were consistently recorded. At 7 days post-insult, Group III (permanent occlusion) had the greatest reduction in the SSEPs recorded ipsilaterally and contralaterally. Groups I and II (transient ischemic groups) also had depressant SSEPs recorded from the ipsilateral ischemic and the contralateral intact brain (electrophysiological diaschisis). However, prolonged ischemia resulted in greater brain infarction and increased neurological deficits in addition to greater reductions in the ipsilateral and the contralateral SSEPs. Conclusion: Early reperfusion facilitates the electrophysiological recovery in both ipsilateral lesional and the contralateral intact brain, which may be closely relevant to post-injury brain rewiring. We also demonstrated that contralateral electrophysiological diaschisis could be greatly reversed by early reperfusion and is independent of the lesion size of striatum.
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U2 - 10.1179/016164109X12581096870032
DO - 10.1179/016164109X12581096870032
M3 - Article
VL - 32
SP - 828
EP - 834
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 8
ER -