Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis

A case report and review of literature

Pei-Chun Hsieh, Shu Min Chen, Yao-Hong Guo, Da-Shen Kuan, Wei Jang Yen, Wen Chen Chang, Yu-Ching Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack of MS, she suffered from long-lasting paroxysmal dystonia in her left hand. Despite treatment with pulse high-dose intravenous methylprednisolone, interferon, and baclofen, along with occupational therapy, the dystonia persisted and significantly bothered her daily activities. Finally, she was treated with oral acetazolamide (250 mg, three times a day for 4 days), which was very effective for the control of her dystonia. The dystonic movement subsided without recurrence in a follow-up of 17 months. We advocate this effective and safe treatment for patients with paroxysmal dystonia associated with MS.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalNeuropsychiatric Disease and Treatment
Volume9
DOIs
Publication statusPublished - 2013 Apr 3

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Acetazolamide
Dystonia
Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Baclofen
Occupational Therapy
Methylprednisolone
Interferons
Hand
Quality of Life
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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title = "Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis: A case report and review of literature",
abstract = "Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack of MS, she suffered from long-lasting paroxysmal dystonia in her left hand. Despite treatment with pulse high-dose intravenous methylprednisolone, interferon, and baclofen, along with occupational therapy, the dystonia persisted and significantly bothered her daily activities. Finally, she was treated with oral acetazolamide (250 mg, three times a day for 4 days), which was very effective for the control of her dystonia. The dystonic movement subsided without recurrence in a follow-up of 17 months. We advocate this effective and safe treatment for patients with paroxysmal dystonia associated with MS.",
author = "Pei-Chun Hsieh and Chen, {Shu Min} and Yao-Hong Guo and Da-Shen Kuan and Yen, {Wei Jang} and Chang, {Wen Chen} and Yu-Ching Lin",
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AU - Chen, Shu Min

AU - Guo, Yao-Hong

AU - Kuan, Da-Shen

AU - Yen, Wei Jang

AU - Chang, Wen Chen

AU - Lin, Yu-Ching

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AB - Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack of MS, she suffered from long-lasting paroxysmal dystonia in her left hand. Despite treatment with pulse high-dose intravenous methylprednisolone, interferon, and baclofen, along with occupational therapy, the dystonia persisted and significantly bothered her daily activities. Finally, she was treated with oral acetazolamide (250 mg, three times a day for 4 days), which was very effective for the control of her dystonia. The dystonic movement subsided without recurrence in a follow-up of 17 months. We advocate this effective and safe treatment for patients with paroxysmal dystonia associated with MS.

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