Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis: A case report and review of literature

Pei Chun Hsieh, Shu Min Chen, Yao Hong Guo, Ta Shen Kuan, Wei Jang Yen, Wen Chen Chang, Yu Ching Lin

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4 Citations (Scopus)

Abstract

Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack of MS, she suffered from long-lasting paroxysmal dystonia in her left hand. Despite treatment with pulse high-dose intravenous methylprednisolone, interferon, and baclofen, along with occupational therapy, the dystonia persisted and significantly bothered her daily activities. Finally, she was treated with oral acetazolamide (250 mg, three times a day for 4 days), which was very effective for the control of her dystonia. The dystonic movement subsided without recurrence in a follow-up of 17 months. We advocate this effective and safe treatment for patients with paroxysmal dystonia associated with MS.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalNeuropsychiatric Disease and Treatment
Volume9
DOIs
Publication statusPublished - 2013 Apr 3

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All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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