Effect of dialysis modalities on risk of hospitalization for gastrointestinal bleeding

Chieh Hsin Huang, Jo Yen Chao, Tsai Chieh Ling, Jia Ling Wu, Junne Ming Sung, Chien Yao Sun, Ya-Yun Cheng, Yu Tzu Chang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Dialysis patients are at risk of both thromboembolic and bleeding events, while thromboembolism prevention and treatment may confer a risk of major bleeding. Gastrointestinal (GI) bleeding is a great concern which can result in high subsequent mortality rates. Our object was to clarify whether hemodialysis (HD) and peritoneal dialysis (PD) confer different incidence of GI bleeding, and further assist individualized decision-making on dialysis modalities. We conducted a population-based retrospective cohort study which included all incident dialysis patients above 18 years old derived from the National Health Insurance database from 1998 to 2013 in Taiwan. 6296 matched pairs of HD and PD patients were identified. A propensity score matching method was used to minimize the selection bias. The adjusted hazard ratio for GI bleeding was 1.13 times higher in the HD group than in the PD group, and data from the unmatched cohort and the stratified analysis led to similar results. Among subgroup analysis, we found that the use of anticoagulants will induce a much higher incidence of GI bleeding in HD patients as compared to in PD patients. We concluded that PD is associated with a lower GI bleeding risk than HD, and is especially preferred when anticoagulation is needed.

Original languageEnglish
Article number52
JournalScientific reports
Issue number1
Publication statusPublished - 2023 Dec

All Science Journal Classification (ASJC) codes

  • General


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