Effect of dietary vitamin D3 on T helper-related activities of lupus- prompt New Zealand black/New Zealand white F1 mice

Research output: Contribution to journalArticle

Abstract

We investigated the effect of dietary vitamin D3 on T helper-related activities and progress of lupus in NZB/NZW F1 mice. Mice were fed with 0.4 or 2 μg vitamin D3 dissolved in 50 μL olive oil every other day. Expression of T cell-related cytokine genes including those of IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 and IFN-γ was monitored during the disease course by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). In addition, total serum IgG1 and IgG2a and anti-dsDNA antibody were measured. We observed a prolonged survival of mice receiving 2μg of vitamin D3 as compared with control mice. However, vitamin D3 did not significantly affect the anti-DNA antibody formation, IgG subtype proportion, or cytokine expression profile.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalJournal of Food and Drug Analysis
Volume7
Issue number3
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

Fingerprint Dive into the research topics of 'Effect of dietary vitamin D3 on T helper-related activities of lupus- prompt New Zealand black/New Zealand white F1 mice'. Together they form a unique fingerprint.

  • Cite this