Effect of GABAA receptor antagonist bicuculline methiodide on hypotension in endotoxin-intoxicated rats

Dur Zong Hsu, Ming-Yi Liu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

γ-Aminobutyric acid (GABA) receptor plays an important regulatory role in human and animal blood pressure; however, whether a GABAergic mechanism is involved in endotoxin intoxication-associated hypotension has never been reported. In vivo effect of the GABAA receptor antagonist bicuculline methiodide (BMI) on mean arterial pressure (MAP), heart rate (HR), and serum nitrite levels were investigated in endotoxin (lipopolysaccharide; LPS)-treated rats. BMI increased MAP and decreased HR in LPS-stimulated rats. DOAV ([deamino-Pen, O-Me-Tyr, Arg3]-vasopressin), an arginine vasopressin (AVP) antagonist, reversed the hemodynamic improvement resulted from BMI in LPS-intoxicated rats. Based on a two-factor (BMI treatment by LPS dose) factorial design, BMI reduced the serum nitrite production induced by LPS. DOAV plus BMI, however, did not affect the serum nitrite level in LPS-intoxicated rats. Thus, GABA receptor antagonist BMI might attenuate hypotension in endotoxin intoxication in rats.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalToxicology
Volume200
Issue number2-3
DOIs
Publication statusPublished - 2004 Aug 5

All Science Journal Classification (ASJC) codes

  • Toxicology

Fingerprint Dive into the research topics of 'Effect of GABA<sub>A</sub> receptor antagonist bicuculline methiodide on hypotension in endotoxin-intoxicated rats'. Together they form a unique fingerprint.

Cite this