Effect of Lavender essential oil on LPS-stimulated inflammation

Mei Yu Huang, May Hua Liao, Yang Kao Wang, Yung Sheng Huang, Hsiao Chuan Wen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Lavender essential oil (LEO) is one the most favorite and widely used essential oils in aromatherapy. Many studies have demonstrated its functions in calming, assisting sleep, reducing pain and muscular spasms and its antiseptic function. To date, however, the mechanism of LEO on inflammation response is not well understood. In this study, we examined the effect of LEO on 5 μg/ml lipopolysaccharide (LPS) induced inflammation reaction in human monocyte THP-1 cells. We found treatment of 0.1% LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells. Treatment with LEO down-regulated both LPS-induced protein levels of phospho-NF-κB and membrane Toll-llike receptor 4. To determine whether the chaperone protein was involved in the reaction, we determined the levels of Heat Shock Protein 70 (HSP70). Our results showed that LEO increased HSP70 expression in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited LPS-induced inflammatory effect might be associated with the expression of HSP70.

Original languageEnglish
Pages (from-to)845-859
Number of pages15
JournalAmerican Journal of Chinese Medicine
Volume40
Issue number4
DOIs
Publication statusPublished - 2012 Jul 30

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All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

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