The purpose of this study was to investigate stress distributions on mandible around screw holes, condylar prosthesis and fixed screws with three types of distributed positions of fixed screws for prosthetic temporomandibular joint (TMJ) replacement. The finite element model was consisted of a defected mandible of condylar resection (including cortical and concellous bone), the condylar prosthesis and fixed screws. The five principal muscles were applied as loading condition to simulate the activity of mouth closing, and boundary condition was fixed at condylar and incisive regions of mandible where position of the mandible was adjusted at the state of 5mm mouth opening. The number of elements and nodes in this finite element model of this study were 135466 and 214575 respectively. The peak stress concentrations of the mandible around the screw holes were detected mainly at the most anterior screw in all of the FE models except the model A. The trend of the maximum stress of the three models at the fixed screws was similar to that at the mandible. This study concluded that the distribution of fixed screws of the Model B was better option for decreasing the stress-induced failure.