TY - JOUR
T1 - Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats
AU - Chandrasekaran, Victor Raj Mohan
AU - Wan, Chang Hsin
AU - Liu, Li Lian
AU - Hsu, Dur Zong
AU - Liu, Ming Yie
PY - 2008/8
Y1 - 2008/8
N2 - Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
AB - Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
UR - http://www.scopus.com/inward/record.url?scp=52149094783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52149094783&partnerID=8YFLogxK
U2 - 10.1097/SHK.0b013e318160dd6b
DO - 10.1097/SHK.0b013e318160dd6b
M3 - Article
C2 - 18091569
AN - SCOPUS:52149094783
SN - 1073-2322
VL - 30
SP - 217
EP - 221
JO - Shock
JF - Shock
IS - 2
ER -