Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats

Victor Raj Mohan Chandrasekaran, Chang Hsin Wan, Li Lian Liu, Dur Zong Hsu, Ming Yie Liu

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalShock
Volume30
Issue number2
DOIs
Publication statusPublished - 2008 Aug 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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