TY - JOUR
T1 - Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats
T2 - Involvement of nitric oxide and proinflammatory cytokines
AU - Hsu, Dur Zong
AU - Su, Shih Bin
AU - Chien, Se Ping
AU - Chiang, Po Jung
AU - Li, Ya Hui
AU - Lo, Ya Ju
AU - Liu, Ming-Yi
PY - 2005/9/1
Y1 - 2005/9/1
N2 - This study aimed to investigate the effect of sesame oil on oxidative stress-associated renal injury induced by lipopolysaccharide in rats. The effects of sesame oil on renal injury, oxidative stress, hydroxyl radical, superoxide anion, nitric oxide, and proinflammatory cytokines were assessed after a lipopolysaccharide challenge. Sesame oil attenuated lipopolysaccharide- induced renal injury, decreased lipid peroxidation, increased the activities of superoxide dismutase, catalase, and glutathione peroxidase, reduced hydroxyl radical generation and nitric oxide production, and had no effect on superoxide anion generation in lipopolysaccharide-challenged rats. In addition, sesame oil significantly decreased tumor necrosis factor-α and interleukin 1β production 1 and 6 h, respectively, after lipopolysaccharide administration in mice. Thus, sesame oil attenuates oxidative stress-associated renal injury via reduction of the production of nitric oxide and the generation of proinflammatory cytokines in endotoxemic rats.
AB - This study aimed to investigate the effect of sesame oil on oxidative stress-associated renal injury induced by lipopolysaccharide in rats. The effects of sesame oil on renal injury, oxidative stress, hydroxyl radical, superoxide anion, nitric oxide, and proinflammatory cytokines were assessed after a lipopolysaccharide challenge. Sesame oil attenuated lipopolysaccharide- induced renal injury, decreased lipid peroxidation, increased the activities of superoxide dismutase, catalase, and glutathione peroxidase, reduced hydroxyl radical generation and nitric oxide production, and had no effect on superoxide anion generation in lipopolysaccharide-challenged rats. In addition, sesame oil significantly decreased tumor necrosis factor-α and interleukin 1β production 1 and 6 h, respectively, after lipopolysaccharide administration in mice. Thus, sesame oil attenuates oxidative stress-associated renal injury via reduction of the production of nitric oxide and the generation of proinflammatory cytokines in endotoxemic rats.
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U2 - 10.1097/01.shk.0000172366.73881.c7
DO - 10.1097/01.shk.0000172366.73881.c7
M3 - Article
C2 - 16135968
AN - SCOPUS:24644431868
SN - 1073-2322
VL - 24
SP - 276
EP - 280
JO - Shock
JF - Shock
IS - 3
ER -