Effect of solution viscosity on generating long DNA nanostrands array via patterned molecular combing

Jun Jie Cheng, Yuan Hsin Chang, Wan Yu Huang, Yi-Je Juang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, we have investigated the effect of solution viscosity on generating the aligned and long DNA nanostrands array via modified molecular combing/soft lithography technique (or patterned molecular combing). By using the solution with higher viscosity, a low peeling-off speed can be applied to generate the long DNA nanostrands and the thornlike structures can be eliminated effectively. The DNA nanostrands array can also be generated by utilizing the polydimethylsiloxane stamp having microwells with larger diameter; however, variation of the lengths of the DNA nanostrands becomes greater as the solution viscosity and the size of microwells increase.

Original languageEnglish
Article number244101
JournalApplied Physics Letters
Volume94
Issue number24
DOIs
Publication statusPublished - 2009 Jun 29

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deoxyribonucleic acid
viscosity
peeling
lithography

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

Cite this

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Effect of solution viscosity on generating long DNA nanostrands array via patterned molecular combing. / Cheng, Jun Jie; Chang, Yuan Hsin; Huang, Wan Yu; Juang, Yi-Je.

In: Applied Physics Letters, Vol. 94, No. 24, 244101, 29.06.2009.

Research output: Contribution to journalArticle

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