Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women: Tianliao old people (TOP) study 07

Yin-Fan Chang, Chin-Sung Chang, Mei Wen Wang, Chun Feng Wu, Chuan-Yu Chen, Hsuan Jui Chang, Po Hsiu Kuo, Chih-Hsing Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3%(Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

Original languageEnglish
Article numbere0161773
JournalPLoS ONE
Volume11
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

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osteoporosis
spine (bones)
Osteoporosis
body mass index
X-radiation
Spine
Body Mass Index
X-Rays
X rays
odds ratio
confidence interval
Logistic Models
Odds Ratio
Confidence Intervals
lumbar spine
Femur Neck
bone density
thighs
hips
Radiography

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{d32c0df30bec47ad80ed3fb84e80effc,
title = "Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women: Tianliao old people (TOP) study 07",
abstract = "Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7{\%}). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3{\%}(Model III, age-standardized 78.1{\%}). The diagnostic discordance was 17.4{\%} in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95{\%} confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95{\%} CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.",
author = "Yin-Fan Chang and Chin-Sung Chang and Wang, {Mei Wen} and Wu, {Chun Feng} and Chuan-Yu Chen and Chang, {Hsuan Jui} and Kuo, {Po Hsiu} and Chih-Hsing Wu",
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month = "9",
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language = "English",
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journal = "PLoS One",
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Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women : Tianliao old people (TOP) study 07. / Chang, Yin-Fan; Chang, Chin-Sung; Wang, Mei Wen; Wu, Chun Feng; Chen, Chuan-Yu; Chang, Hsuan Jui; Kuo, Po Hsiu; Wu, Chih-Hsing.

In: PLoS ONE, Vol. 11, No. 9, e0161773, 01.09.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women

T2 - Tianliao old people (TOP) study 07

AU - Chang, Yin-Fan

AU - Chang, Chin-Sung

AU - Wang, Mei Wen

AU - Wu, Chun Feng

AU - Chen, Chuan-Yu

AU - Chang, Hsuan Jui

AU - Kuo, Po Hsiu

AU - Wu, Chih-Hsing

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3%(Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

AB - Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3%(Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

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