Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women: Tianliao old people (TOP) study 07

Yin Fan Chang, Chin Sung Chang, Mei Wen Wang, Chun Feng Wu, Chuan Yu Chen, Hsuan Jui Chang, Po Hsiu Kuo, Chih Hsing Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3%(Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

Original languageEnglish
Article numbere0161773
JournalPloS one
Volume11
Issue number9
DOIs
Publication statusPublished - 2016 Sep

Fingerprint

osteoporosis
spine (bones)
Osteoporosis
body mass index
X-radiation
Spine
Body Mass Index
X-Rays
X rays
odds ratio
confidence interval
Logistic Models
Odds Ratio
Confidence Intervals
lumbar spine
Femur Neck
bone density
thighs
hips
Radiography

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

@article{d32c0df30bec47ad80ed3fb84e80effc,
title = "Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women: Tianliao old people (TOP) study 07",
abstract = "Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7{\%}). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3{\%}(Model III, age-standardized 78.1{\%}). The diagnostic discordance was 17.4{\%} in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95{\%} confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95{\%} CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.",
author = "Chang, {Yin Fan} and Chang, {Chin Sung} and Wang, {Mei Wen} and Wu, {Chun Feng} and Chen, {Chuan Yu} and Chang, {Hsuan Jui} and Kuo, {Po Hsiu} and Wu, {Chih Hsing}",
year = "2016",
month = "9",
doi = "10.1371/journal.pone.0161773",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women : Tianliao old people (TOP) study 07. / Chang, Yin Fan; Chang, Chin Sung; Wang, Mei Wen; Wu, Chun Feng; Chen, Chuan Yu; Chang, Hsuan Jui; Kuo, Po Hsiu; Wu, Chih Hsing.

In: PloS one, Vol. 11, No. 9, e0161773, 09.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of age and body mass index on thoracolumbar spine X-ray for diagnosing osteoporosis in elderly women

T2 - Tianliao old people (TOP) study 07

AU - Chang, Yin Fan

AU - Chang, Chin Sung

AU - Wang, Mei Wen

AU - Wu, Chun Feng

AU - Chen, Chuan Yu

AU - Chang, Hsuan Jui

AU - Kuo, Po Hsiu

AU - Wu, Chih Hsing

PY - 2016/9

Y1 - 2016/9

N2 - Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3%(Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

AB - Purpose: The aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis. Methods: We randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated. Results: The overall prevalence of osteoporosis was 78.3%(Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88-0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00-1.15, p < 0.05). Conclusions: A thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

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