Effects of B Value on Quantification of Rapid Diffusion Kurtosis Imaging in Normal and Acute Ischemic Brain Tissues

Ming Chung Chou, Cheng Wen Ko, Yu Hsien Chiu, Hsiao Wen Chung, Ping Hong Lai

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

PURPOSE: Diffusion kurtosis imaging (DKI) has been widely used to characterize brain tissue alterations. Diffusion-weighting factor or b value plays an important role in the measurement of rapid DKI and may have influential effects on them. The purpose of this study was to investigate the effects of b value on rapid DKI indices in normal and acute ischemic brain tissues.

MATERIALS AND METHODS: This study enrolled 10 healthy subjects and 4 acute ischemic stroke patients. Three repeated DKI data with 6 high b values (500, 750, 1000, 1500, 2000, 3000 s/mm) were acquired from healthy subjects, whereas nonrepeated DKI data with 3 high b values (1000, 2000, 3000 s/mm) were acquired from ischemic stroke patients. The DKI datasets were decomposed into several rapid DKI datasets consisting of 1 b0 and 2 high b values for comparisons.

RESULTS: The results showed that b value significantly impacted the reproducibility and accuracy of DKI indices. The comparisons demonstrated that DKI with b = (0, 1000, 3000) s/mm exhibited more reproducible and accurate DKI indices than other DKI datasets in normal brain tissues, and similar results were noticed in acute ischemic brain tissue.

CONCLUSIONS: We concluded that b value significantly impacted the quantification of DKI indices in both normal and acute ischemic brain tissues.

Original languageEnglish
Pages (from-to)868-876
Number of pages9
JournalJournal of computer assisted tomography
Volume41
Issue number6
DOIs
Publication statusPublished - 2017 Nov 1

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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