Effects of blue-light-induced free radical formation from catechin hydrate on the inactivation of acinetobacter baumannii, including a carbapenem-resistant strain

Meei Ju Yang, Yi An Hung, Tak-Wah Wong, Nan-Yao Lee, Jeu Ming P. Yuann, Shiuh Tsuen Huang, Chun Yi Wu, Iou Zen Chen, Ji Yuan Liang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Catechin is a flavan-3-ol, a derivative of flavans, with four phenolic hydroxyl groups, which exhibits a wide range of physiological properties. Chromatographic analyses were employed to examine the effects of blue light irradiation on the changes of catechin hydrate in an alkaline condition. In particular, the detection of a superoxide anion radical (O 2 ), a reactive oxygen species (ROS), and the inactivation of Acinetobacter baumannii (A. baumannii)—including a carbapenem-resistant A. baumannii (CRAB)—was investigated during the photoreaction of catechin hydrate. Following basification with blue light irradiation, the transparent solution of catechin hydrate turned yellowish, and a chromogenic catechin dimer was separated and identified as a proanthocyanidin. Adding ascorbic acid during the photolytic treatment of catechin hydrate decreased the dimer formation, suggesting that ascorbic acid can suppress the photosensitive oxidation of catechin. When catechin hydrate was irradiated by blue light in an alkaline solution, O 2 was produced via photosensitized oxidation, enhancing the inactivation of A. baumannii and CRAB. The present findings on the photon-induced oxidation of catechin hydrate provides a safe practice for the inactivation of environmental microorganisms.

Original languageEnglish
Article number1631
JournalMolecules
Volume23
Issue number7
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Acinetobacter baumannii
Carbapenems
Catechin
Hydrates
hydrates
deactivation
free radicals
Free Radicals
Light
ascorbic acid
oxidation
dimers
Superoxides
Dimers
Oxidation
Ascorbic Acid
irradiation
inorganic peroxides
microorganisms
Irradiation

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Yang, Meei Ju ; Hung, Yi An ; Wong, Tak-Wah ; Lee, Nan-Yao ; Yuann, Jeu Ming P. ; Huang, Shiuh Tsuen ; Wu, Chun Yi ; Chen, Iou Zen ; Liang, Ji Yuan. / Effects of blue-light-induced free radical formation from catechin hydrate on the inactivation of acinetobacter baumannii, including a carbapenem-resistant strain. In: Molecules. 2018 ; Vol. 23, No. 7.
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Effects of blue-light-induced free radical formation from catechin hydrate on the inactivation of acinetobacter baumannii, including a carbapenem-resistant strain. / Yang, Meei Ju; Hung, Yi An; Wong, Tak-Wah; Lee, Nan-Yao; Yuann, Jeu Ming P.; Huang, Shiuh Tsuen; Wu, Chun Yi; Chen, Iou Zen; Liang, Ji Yuan.

In: Molecules, Vol. 23, No. 7, 1631, 01.01.2018.

Research output: Contribution to journalArticle

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