Effects of dexamethasone and sex hormones on cytokine-induced cellular adhesion molecule expression in human endothelial cells

Wen Chieh Chen, J. Yu Yun Lee, Wen Chuan Hsieh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The cause or mechanism of the female predisposition in systemic lupus erythematosus and progressive systemic sclerosis is largely unknown. Accumulating evidence shows that dysfunction or activation of endothelial cells plays an important role in these conditions. In this study, we investigated the influence of various steroid hormones on the IL-1β (50 U/mL)/TNF-α (50 U/mL) stimulated human dermal microvascular endothelial cell line (HMEC-1) and human umbilical vein endothelial cells (HUVEC). Dexamethasone showed significant inhibition of cytokine-induced ICAM-1 expression in HMEC-1, and E-selectin, VCAM-1 and ICAM-1 expressions in HUVEC. Androgens, especially dihydrotestosterone had a small, but statistically significant suppressive effect in HMEC-1 only. Estrogen exhibited no regulatory function in either cell line. No obvious expression of estrogen and androgen receptors could be demonstrated in either cell by immunostaining. Our study provided some pharmacological evidence that the superior anti-inflammatory effect of glucocorticoids on vasculitis was partly due to their inhibition of the CAM expression in endothelial cells. More studies are needed to determine if androgens could have a protective effect in vasculitis or vasculopathy associated with connective tissue diseases.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalEuropean Journal of Dermatology
Volume12
Issue number5
Publication statusPublished - 2002 Sep 1

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Gonadal Steroid Hormones
Dexamethasone
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Intercellular Adhesion Molecule-1
Cytokines
Vasculitis
Androgens
Diffuse Scleroderma
Cell Line
E-Selectin
Connective Tissue Diseases
Vascular Cell Adhesion Molecule-1
Dihydrotestosterone
Androgen Receptors
Interleukin-1
Estrogen Receptors
Systemic Lupus Erythematosus
Glucocorticoids
Estrogens

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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Effects of dexamethasone and sex hormones on cytokine-induced cellular adhesion molecule expression in human endothelial cells. / Chen, Wen Chieh; Lee, J. Yu Yun; Hsieh, Wen Chuan.

In: European Journal of Dermatology, Vol. 12, No. 5, 01.09.2002, p. 445-448.

Research output: Contribution to journalArticle

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