Effects of enriched branched-chain amino acid supplementation on sarcopenia

Chun Hung Ko, Shin Jiuan Wu, Shan Tair Wang, Yin Fan Chang, Chin Sung Chang, Ta Shen Kuan, Hua Ying Chuang, Chia Ming Chang, Willy Chou, Chih Hsing Wu

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA powder twice a day for five weeks followed by a discontinuation period of 12 weeks. We evaluated sarcopenic parameters, including grip strength, 6-meter gait speed, and bioelectrical-impedance-analysis-derived skeletal mass index (SMI), at baseline, 5 weeks, and 17 weeks. We found that both pre-sarcopenic and sarcopenic subjects showed improved SMI, gait speed, and grip strength at 5 weeks. However, all three parameters progressively declined at 17 weeks, especially SMI and grip strength in subjects aged < 65 years and gait speed and grip strength in subjects aged ≥ 65 years. It thus appears that supplementation with enriched BCAAs for 5 weeks correlates with short-term positive effects on sarcopenic parameters but attenuation of those effects following discontinuation for 12 weeks.

Original languageEnglish
Pages (from-to)15091-15103
Number of pages13
JournalAging
Volume12
Issue number14
DOIs
Publication statusPublished - 2020 Jul 31

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology

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