Effects of gene-environmental interaction on noise-induced hearing threshold levels for high frequencies (HTLHF)

Cheng Yu Lin; Tung Sheng Shih; Yue Liang Leon Guo; Jiunn Liang Wu; Yih Min Sun; Perng Jy Tsai

doi:10.1021/es200497v

Effects of gene-environmental interaction on noise-induced hearing threshold levels for high frequencies (HTLHF)

Cheng Yu Lin, Tung Sheng Shih, Yue Liang Leon Guo, Jiunn Liang Wu, Yih Min Sun, Perng Jy Tsai

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in L _{eq-8 h} was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L _eq-40y). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile ¹⁰⁵/Ile ¹⁰⁵ genotypes were susceptible to the HTLHF when their L _eq-40y were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.

Original language	English
Pages (from-to)	7128-7134
Number of pages	7
Journal	Environmental Science and Technology
Volume	45
Issue number	17
DOIs	https://doi.org/10.1021/es200497v
Publication status	Published - 2011 Sept 1

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry

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title = "Effects of gene-environmental interaction on noise-induced hearing threshold levels for high frequencies (HTLHF)",

abstract = "In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in L eq-8 h was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L eq-40y). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile 105/Ile 105 genotypes were susceptible to the HTLHF when their L eq-40y were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.",

author = "Lin, {Cheng Yu} and Shih, {Tung Sheng} and Guo, {Yue Liang Leon} and Wu, {Jiunn Liang} and Sun, {Yih Min} and Tsai, {Perng Jy}",

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AU - Lin, Cheng Yu

AU - Shih, Tung Sheng

AU - Guo, Yue Liang Leon

AU - Wu, Jiunn Liang

AU - Sun, Yih Min

AU - Tsai, Perng Jy

PY - 2011/9/1

Y1 - 2011/9/1

N2 - In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in L eq-8 h was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L eq-40y). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile 105/Ile 105 genotypes were susceptible to the HTLHF when their L eq-40y were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.

AB - In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in L eq-8 h was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L eq-40y). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile 105/Ile 105 genotypes were susceptible to the HTLHF when their L eq-40y were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.

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Effects of gene-environmental interaction on noise-induced hearing threshold levels for high frequencies (HTLHF)

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