Effects of growth hormone treatment on height, weight, and obesity in Taiwanese patients with prader-willi syndrome

Hsiang Yu Lin, Shuan Pei Lin, Li Ping Tsai, Mei Chyn Chao, Ming Ren Chen, Chih Kuang Chuang, Chi Yu Huang, Fuu Jen Tsai, I. Ching Chou, Pao Ching Chiu, Cheng Hung Huang, Jui Lung Yen, Ju Li Lin, Pao Lin Kuo

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9 Citations (Scopus)

Abstract

Background: Information regarding the efficacy of growth hormone (GH) therapy in Asian Prader-Willi syndrome (PWS) patients is lacking. We report our experience with GH treatment in children with PWS in Taiwan. Methods: Forty-six PWS patients (27 males, 19 females; age range, 1 year 4 months to 13 years 7 months) who received and/or who are currently receiving GH treatment (0.1 IU/kg/day subcutaneously) for a period from 1 year to 3 years were retrospectively analyzed. We evaluated height, weight, body mass index (BMI) and Rohrer index, before and after GH treatment. Results: After patients had received GH for 1, 2 and 3 years, a significant improvement in mean height standard deviation score (SDS) was noted from -1.24 to -0.31 (p < 0.01), 0.00 (p < 0.001) and -0.26 (p < 0.001), respectively. Mean BMI SDS decreased significantly from 1.93 to 1.13 (p < 0.05) after 1 year of treatment; however, no significant changes were observed afterward. Mean Rohrer index decreased significantly, from 224.2 to 186.6 (p < 0.001), 178.9 (p < 0.001) and 169.3 (p < 0.001). No significant gender or genotype pattern differences were noted among the 4 parameters examined. Conclusion: This 3-year, retrospective study indicates that PWS patients benefit from GH therapy in height increase and improved body composition.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalJournal of the Chinese Medical Association
Volume71
Issue number6
DOIs
Publication statusPublished - 2008 Jun

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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