Effects of laparoscopic ovarian drilling on young adult women with polycystic ovarian syndrome

Meng Hsing Wu, Mei Feng Huang, Shaw Jenq Tsai, Hsien An Pan, Yueh Chin Cheng, Yue Shan Lin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Study Objective. To assess changes in serum hormone levels and ovarian stromal blood flow after laparoscopic ovarian drilling (LOD) in young adult women with polycystic ovary syndrome (PCOS). Design. Prospective, nonrandomized study (Canadian Task Force classification II-1). Setting. Tertiary care, major teaching hospitals. Patients. Anovulatory young women with PCOS who were resistant to clomiphene citrate. Intervention. Laparoscopic ovarian drilling. Measurements and Main Results. To evaluate the endocrinological effects of LOD, serum leptin, insulin-like growth factor-1, estrone (E1), and estradiol were measured before and after ovarian drilling in the early follicular phase. Three-dimensional transabdominal power Doppler examinations were performed to determine the effects of LOD. Serum leptin was correlated with body mass index (BMI) before LOD. Levels of BMI, fasting blood sugar, and leptin were higher and LH, LH/FSH, and the sugar/insulin ratio were lower in the obese group. There were significant decreases in the free androgen index, and total testosterone, luteinizing hormone (LH), and LH/follicle-stimulating hormone (FSH) levels, and a significant increase in sex hormone-binding globulin (SHBG) concentration in the 3 months after the operation. The vascularization index and vascularization flow index of the intraovarian stroma significantly decreased after treatment. Reversed correlations between leptin and LH, LH/FSH, E1, thyroid-stimulating hormone, and SHBG were noted 3 months after the operation compared with levels obtained before the operation. Conclusions. Treatment of young adult women with PCOS using LOD did not influence leptin levels but changed the ovarian stromal blood flow dynamics during short-term follow-up. The surgical procedure may be beneficial both to endocrine profiles and to intraovarian stromal flow in patients with PCOS.

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalJournal of the American Association of Gynecologic Laparoscopists
Volume11
Issue number2
DOIs
Publication statusPublished - 2004 May

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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