Effects of lithium and haloperidol on human sperm motility in‐vitro

Meng‐Ru ‐R Shen, Rei‐Cheng ‐C Yang, Shun‐Sheng ‐S Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Abstract— Two psychotropic drugs, lithium and haloperidol, were evaluated for their in‐vitro effects on sperm motility using a transmembrane migration method. Sperm motility was measured either immediately after semen had been mixed with the drug or after a 2 h incubation period at 37°C. Lithium inhibited human sperm motility in a dose‐dependent manner with an EC50 of 10 Mm when the semen‐lithium mixture had been incubated. Sperm motility was increased to 127% of control when semen had been incubated with 0027 μm haloperidol; this concentration was within the therapeutic range. 1992 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)534-536
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume44
Issue number6
DOIs
Publication statusPublished - 1992 Jun

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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