Effects of multiple virus coinfections on disease progression in HIV-positive patients

Biehuoy Shieh, Ming Jen Chang, Wen-Chien Ko, Eng Jun Chen, Jaw Ching Wu, Chia Fang Lee, Ting-Tsung Chang, Ching Li

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Since virus infections in AIDS patients are mostly inevitable and as they frequently cause disease deterioration and therapeutic failures, a comprehensive investigation was made of the influence of the coinfections of 9 well-known viruses on disease progression in patients infected with human immunodeficiency virus type 1 (HIV). Methods: A cross-sectional study of 62 HIV-positive patients was conducted to correlate the prevalence rates for the 9 viruses with the alanine aminotransferase (ALT) levels and CD4 cell counts of the patients. Results: The rates of HIV-positive patients infected with the 9 viruses are significantly higher than those of the control groups. Furthermore, almost one third of the patients in the studied group was coinfected with transfusion-transmitted virus (TTV) and manifested significantly higher ALT levels (p = 0.020), and these were raised further if coinfection with TTV and human hepatitis C virus had occurred (p = 0.010). By analyzing CD4 cell counts, the only significant effect on AIDS progression which could be detected was coinfection with human herpesvirus 8. Conclusion: This result confirmed that immune-suppressed persons are more vulnerable to common virus infections. Unlike hepatitis B or C virus, TTV seems to accelerate the progression of chronic hepatitis in HIV-infected patients.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalIntervirology
Volume46
Issue number2
DOIs
Publication statusPublished - 2003 Apr 15

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Coinfection
Disease Progression
HIV-1
Viruses
Torque teno virus
Virus Diseases
CD4 Lymphocyte Count
Alanine Transaminase
Hepacivirus
Acquired Immunodeficiency Syndrome
Human Herpesvirus 8
Chronic Hepatitis
Hepatitis B virus
Cross-Sectional Studies
Control Groups

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Shieh, B., Chang, M. J., Ko, W-C., Chen, E. J., Wu, J. C., Lee, C. F., ... Li, C. (2003). Effects of multiple virus coinfections on disease progression in HIV-positive patients. Intervirology, 46(2), 105-113. https://doi.org/10.1159/000069745
Shieh, Biehuoy ; Chang, Ming Jen ; Ko, Wen-Chien ; Chen, Eng Jun ; Wu, Jaw Ching ; Lee, Chia Fang ; Chang, Ting-Tsung ; Li, Ching. / Effects of multiple virus coinfections on disease progression in HIV-positive patients. In: Intervirology. 2003 ; Vol. 46, No. 2. pp. 105-113.
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Effects of multiple virus coinfections on disease progression in HIV-positive patients. / Shieh, Biehuoy; Chang, Ming Jen; Ko, Wen-Chien; Chen, Eng Jun; Wu, Jaw Ching; Lee, Chia Fang; Chang, Ting-Tsung; Li, Ching.

In: Intervirology, Vol. 46, No. 2, 15.04.2003, p. 105-113.

Research output: Contribution to journalArticle

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