Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

Chao Chun Yang, Chin Han Wu, Tak Wah Wong, Feng Jie Lai, Kai Che Wei, Tzu Kai Lin, Chrang Shi Lin, Juemin Zhao, Leihong Xiang, Chao Hsing Kao, Ying Jan Wang, Cheng Che Eric Lan, Hamm Ming Sheu

Research output: Contribution to journalArticlepeer-review

Abstract

SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
JournalJournal of Dermatology
Volume48
Issue number3
DOIs
Publication statusPublished - 2021 Mar

All Science Journal Classification (ASJC) codes

  • Dermatology

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