Efficient fucoidan extraction and purification from Sargassum cristaefolium and preclinical dermal biological activity assessments of the purified fucoidans

En Ting Lin, Yi Chieh Lee, Hui Min David Wang, Chen Yaw Chiu, Yu Kaung Chang, Chun Yung Huang, Chia Che Chang, Pei Chien Tsai, Jo Shu Chang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Fucoidan is a heterologous polysaccharide consisting mainly of L-fucose with sulfuric acid functional groups, and it is considered to be a repository of bioactive compounds with excellent therapeutic and medical potential, such as antioxidant, anti-inflammatory, antiangiogenic, antitumor, and antibacterial capabilities. Methods: Subcritical water extraction was used to extract fucoidan from Sargassum. Fucoidans with different molecular weight (LMW) fractions were obtained by H2O2 hydrolysis, and the effect of LMW on their bio-functions was investigated. Significant Findings: Metal chelating, iron-reducing and free radical scavenging properties of purified fucoidans demonstrated outstanding anti-oxidative capacities of SWE fractions. In cellular viability assay, SWE was not inhibitory towards RAW 264.7, HaCaT, and Hs68 cells, even when high dosages were used. Anti-inflammatory activity was brought about by SWE administration after UVB exposure, demonstrating that the injured skin tissue was repaired and collagen was regenerated, as shown by in vitro and in vivo tests.

Original languageEnglish
Article number104294
JournalJournal of the Taiwan Institute of Chemical Engineers
Volume137
DOIs
Publication statusPublished - 2022 Aug

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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