Efficient imaging of midbrain nuclei using inverse double-echo steady-state acquisition

Ming Long Wu, Hing Chiu Chang, Tzu Cheng Chao, Nan Kuei Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose: Imaging of midbrain nuclei using T2- or T2-weighted MRI often entails long echo time, leading to long scan time. In this study, an inverse double-echo steady-state (iDESS) technique is proposed for efficiently depicting midbrain nuclei. Methods: Thirteen healthy subjects participated in this study. iDESS was performed along with two sets of T2-weighted spoiled gradient-echo images (SPGR1, with scan time identical to iDESS and SPGR2, using clinical scanning parameters as a reference standard) for comparison. Generation of iDESS composite images combining two echo signals was optimized for maximal contrast-to-noise ratio (CNR) between the red nuclei and surrounding tissues. Signal-to-noise ratios (SNRs) were calculated from the occipital lobe. Comparison was also made using phase-enhanced images as in standard susceptibility-weighted imaging (SWI). Results: The iDESS images present significantly higher SNR efficiency (171.3) than SPGR1 (158.7, p = 0.013) and SPGR2 (95.5, p < 10-8). iDESS CNR efficiency (19.2) is also significantly greater than SPGR1 (6.9, p < 10-6) and SPGR2 (14.3, p = 0.0016). Compared with DESS, iDESS provides further advantage on enhanced phase information and hence improved contrast on SWI-processed images. Conclusions: iDESS efficiently depicts midbrain nuclei with improved CNR efficiency, increased SNR efficiency, and reduced scan time and is less prone to susceptibility signal loss from air-tissue interfaces.

Original languageEnglish
Pages (from-to)4367-4374
Number of pages8
JournalMedical Physics
Issue number7
Publication statusPublished - 2015 Jul 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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