Efficient synthesis of 2-(N-Substituted)-2-imidazolines and 2-(N-Substituted)-1,4,5, 6-tetrahydropyrimidines

Wai Ming Kan, Shih Hsun Lin, Ching Yuh Chern

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A general method for the preparation of 2-(N-Substituted)-2-imidazolines and 2-(N-Substituted)-1,4,5,6-tetrahydropyrimidines is described. These heterocycles can be synthesized from their respective anilines with 2-chloro-2-imidazoline or 2-chloro-1,4,5,6-tetrahydropyrimidine, generated in situ from imidazolidin-2-one and tetrahydropyrimidin-2(1H)-one activated by dimethyl chlorophosphate, in good to excellent yields.

Original languageEnglish
Pages (from-to)2633-2639
Number of pages7
JournalSynthetic Communications
Volume35
Issue number20
DOIs
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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