Efficient two-photon luminescence for cellular imaging using biocompatible nitrogen-doped graphene quantum dots conjugated with polymers

Ping Ching Wu, Jiu Yao Wang, Wen Lung Wang, Chia Yuan Chang, Chia Hung Huang, Kun Lin Yang, Jui Cheng Chang, Chih Li Lilian Hsu, Shih Yao Chen, Ting Mao Chou, Wen Shuo Kuo

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Nitrogen-doped graphene quantum dot (N-GQD) nanomaterials conjugated with polyethylenimine (PEI)-polystyrene sulfonate (PSS)-anti-epidermal growth factor receptor (AbEGFR) antibody (N-GQD-PEI-PSS-AbEGFR) demonstrated impressive two-photon properties and stability, signifying that they can serve as an effective two-photon contrast agent in two-photon bioimaging. Furthermore, they provided high intensity, brightness, and signal-to-noise ratios at an ultra-low two-photon excitation (TPE) power level in an observation extending to a deep, three-dimensional depth.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalNanoscale
Volume10
Issue number1
DOIs
Publication statusPublished - 2018 Jan 7

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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